Mechanism of secretory cargo sorting at the trans-Golgi Network

• Applicant: Professorin Julia von Blume, Ph.D.
• Subject Area: Cell Biology
• Term: from 2016 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 323442537

• Final Report Year: 2020

No abstract available

Publications

• Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins at the trans-Golgi Network. 2018. Dev Cell. 47 (4): 464-478
  Deng, Yongqiang; Pakdel, Mehrshad; Blank, Birgit; Sundberg, Emma L.; Burd, Christopher G. & von Blume, Julia
  
• Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature. 2019 May;569(7755):236-240
  Silvestre-Roig, Carlos; Braster, Quinte; Wichapong, Kanin; Lee, Ernest Y.; Teulon, Jean Marie; Berrebeh, Nihel; Winter, Janine; Adrover, José M.; Santos, Giancarlo Santiago; Froese, Alexander; Lemnitzer, Patricia; Ortega-Gómez, Almudena; Chevre, Raphael; Marschner, Julian; Schumski, Ariane; Winter, Carla; Perez-Olivares, Laura; Pan, Chang; Paulin, Nicole; ... & Soehnlein, Oliver
  
• Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. EMBO Rep. 2019
  Papadopoulou, Alkmini A; Müller, Stephan A; Mentrup, Torben; Shmueli, Merav D; Niemeyer, Johannes; Haug‐Kröper, Martina; von Blume, Julia; Mayerhofer, Artur; Feederle, Regina; Schröder, Bernd; Lichtenthaler, Stefan F & Fluhrer, Regina
  
• Fam20C regulates protein secretion by Cab45 phosphorylation. J Cell Biol. 2020 Jun 1;219(6):e201910089
  Hecht, Tobias Karl-Heinz; Blank, Birgit; Steger, Martin; Lopez, Victor; Beck, Gisela; Ramazanov, Bulat; Mann, Matthias; Tagliabracci, Vincent & von Blume, Julia
  
• Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs. J Cell Biol. 2020 Aug 3;219(8):e201907058
  Pacheco-Fernandez, Natalia; Pakdel, Mehrshad; Blank, Birgit; Sanchez-Gonzalez, Ismael; Weber, Kathrin; Tran, Mai Ly; Hecht, Tobias Karl-Heinz; Gautsch, Renate; Beck, Gisela; Perez, Franck; Hausser, Angelika; Linder, Stefan & von Blume, Julia
  
• Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3. EMBO J. 2020 Jun 22:e103457
  Pigoni, Martina; Hsia, Hung‐En; Hartmann, Jana; Rudan Njavro, Jasenka; Shmueli, Merav D.; Müller, Stephan A.; Güner, Gökhan; Tüshaus, Johanna; Kuhn, Peer‐Hendrik; Kumar, Rohit; Gao, Pan; Tran, Mai Ly; Ramazanov, Bulat; Blank, Birgit; Hipgrave Ederveen, Ag