Development of small molecule inhibitors and stabilizers of dimerization of tRNA-guanine transglycosylase to treat Shigellosis

• Applicant: Professor Dr. Gerhard Klebe
• Subject Area: Pharmacy
• Term: from 2016 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324043133

• Final Report Year: 2020

No abstract available

Publications

• Sugar Acetonides are a Superior Motif for Addressing the Large, Solvent-Exposed Ribose-33 Pocket of tRNA- Guanine Transglycosylase, Chem. Eur. J. 24 (2018) 9957–9967
  Movsisyan, Levon D.; Schäfer, Elisabeth; Nguyen, Andreas; Ehrmann, Frederik R.; Schwab, Anatol; Rossolini, Thomas; Zimmerli, Daniel; Wagner, Björn; Daff, Hamina; Heine, Andreas; Klebe, Gerhard & Diederich, François
  
• Swapping Interface Contacts in the Homodimeric tRNA Guanine Transglycosylase: An Option for Functional Regulation, Angew. Chem. Int Ed. Engl., 57 (2018) 10085-10090
  Ehrmann, Frederik Rainer; Kalim, Jorna; Pfaffeneder, Toni; Bernet, Bruno; Hohn, Christoph; Schäfer, Elisabeth; Botzanowski, Thomas; Cianférani, Sarah; Heine, Andreas; Reuter, Klaus; Diederich, François & Klebe, Gerhard
  
• The Importance of Charge in Perturbing the Aromatic Glue Stabilizing the Protein–Protein Interface of Homodimeric tRNA-Guanine Transglycosylase, ACS Chem. Biol. 15 (2020) 3021–3029
  Nguyen, Andreas; Nguyen, Dzung; Phong Nguyen, Tran Xuan; Sebastiani, Maurice; Dörr, Stefanie; Hernandez-Alba, Oscar; Debaene, François; Cianférani, Sarah; Heine, Andreas; Klebe, Gerhard & Reuter, Klaus