Development of small molecule inhibitors and stabilizers of dimerization of tRNA-guanine transglycosylase to treat Shigellosis

• Applicant: Professor Dr. Gerhard Klebe
• Subject Area: Pharmacy
• Term: from 2016 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 324043133

• Final Report Year: 2020

Final Report Abstract

No abstract available

Publications

• Sugar Acetonides are a Superior Motif for Addressing the Large, Solvent-Exposed Ribose-33 Pocket of tRNA- Guanine Transglycosylase, Chem. Eur. J. 24 (2018) 9957–9967
  L. D. Movsisyan, E. Schäfer, A. Nguyen, F. R. Ehrmann, A. Schwab, T. Rossolini, D. Zimmerli, B. Wagner, H. Daff, A. Heine, G. Klebe, F. Diederich
  
• Swapping Interface Contacts in the Homodimeric tRNA Guanine Transglycosylase: An Option for Functional Regulation, Angew. Chem. Int Ed. Engl., 57 (2018) 10085-10090
  F. R. Ehrmann, J. Kalim, T. Pfaffeneder, B. Bernet, C. Hohn, E. Schäfer, T. Botzanowski, S. Cianférani, A. Heine, K. Reuter, F. Diederich, G. Klebe
  
• The Importance of Charge in Perturbing the Aromatic Glue Stabilizing the Protein–Protein Interface of Homodimeric tRNA-Guanine Transglycosylase, ACS Chem. Biol. 15 (2020) 3021–3029
  A. Nguyen, D. Nguyen, T. X. P. Nguyen, M. Sebastiani, S. Dörr, O. Hernandez-Alba, F. Debaene, S. Cianférani, A. Heine, G. Klebe, K. Reuter