EXC 171:  Microscopy at the Nanometer Range (within DFG Research Centre CMPB)

Final Report Abstract

One of the most important challenges in neuroscience is to unravel the basic mechanisms of neurodegenerative and psychiatric diseases. The Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB) therefore aimed on utilizing the revolutionary developments in advanced microscopy for the discovery of the complex molecular processes that underlie brain development and dysfunction. On this basis, new diagnostic tools and therapeutic strategies have been identified and developed for prevention and treatment of relevant disorders. Basis of the highly successful research alliance was the DFG Research Center Molecular Physiology of the Brain (CMPB), which has been established in 2002 and expanded by the Cluster of Excellence Microscopy at the Nanometer Range in 2006. In the final prolongation phase the two were fused as CNMPB. The CMPB/EXC/CNMPB has profoundly changed the academic landscape in Göttingen, and succeeded in creating an integrated and interdisciplinary neuroscience campus, including groups from the University, the University Medical Center, two Max Planck Institutes, the German Primate Center, and the Laser Laboratory Göttingen e.V. on an equal footing. This development has been supported by creation of key professorships, now tenured, in bridging areas that were not covered before. CNMPB scientists have contributed to international visibility by publishing 1075 peer-reviewed papers in relevant scientific journals since 2006. The most prominent highlight is the Nobel Prize in Chemistry that CNMPB speaker Stefan Hell received in 2014 for the development of stimulated emission depletion (STED) microscopy, and its successfully application to live neuronal tissues. The CNMPB has been catalyst for the creation of interdisciplinary graduate schools, especially in biophysics and neuroscience. In total, 108 doctoral theses were completed, 9 Junior Research Groups were established, and various young CNMPB scientists obtained attractive offers for professor positions subsequent to their CNMPB engagement. CNMPB scientists were involved in establishment of numerous local research consortia (CRCs, FORs, and start-ups). In 2014, the construction of the Center for Biostructural Imaging in Neurodegeneration (BIN) was completed as a straightforward extension of the CNMPB’s goals. Finally, 16 years of cutting-edge CNMPB research provided the basis for the successful proposal of a new life science cluster within the Excellence Strategy of the Federal Government and the Länder. In 2019, the Cluster of Excellence ‘Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells’ and successor of the CNMPB commenced its operations.

Publications

• (2006) Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development. AM J HUM GENET, 79: 668-78
  Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe P, Tarabykin V
  
• (2007) Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2-/y knockout mice. J PHYSIOL, 579: 863-76
  Stettner GM, Huppke P, Brendel C, Richter DW, Gärtner J, Dutschmann M
  
• (2007) Cannabinoid action in the olfactory epithelium. PROC NATL ACAD SCI USA, 104: 2967-72
  Czesnik D, Schild D, Kuduz J, Manzini I
  
• (2007) Fluorescence imaging of amyloid formation in living cells by a functional, tetracysteine-tagged alpha-synuclein. NAT METHODS, 4: 345-51
  Roberti MJ, Bertoncini CW, Klement R, Jares-Erijman EA, Jovin TM
  
• (2008) Microtubule-driven multimerization recruits ase1p onto overlapping microtubules. CURR BIOL, 18: 1713-17
  Kapitein LC, Janson ME, van den Wildenberg SM, Hoogenradd CC, Schmidt CF, Peterman EJ
  
• (2008) Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. PROC NATL ACAD SCI USA, 105 (5): 1710-1715
  Jamain S, Radyushkin K, Hammerschmidt K, Granon S, Boretius S, Varoqueaux F, Ramanantsoa N, Gallego J, Ronnenberg A, Winter D, Frahm J, Fischer J, Bourgeron T, Ehrenreich H, Brose N.
  
• (2008) Satb2 is a postmitotic determinant for upper layer neuron specification in the neocortex. NEURON, 57: 378-92
  Britanova O, de Juan Romero MC, Cheung A, Kwan K, Schwark M, Gyorgy A, Vogel T, Akopov S, Mitkovski M, Agoston D, Sestan N, Molnar Z, Tarabykin V
  
• (2008) The homotetrameric kinesin-5 KLP61F preferentially crosslinks microtubules into antiparallel orientations. CURR BIOL, 18: 1860-64
  Van den Wildenberg SMJL, Tao L, Kapitein LC, Schmidt CF, Scholey JM, Peterman EJG
  
• (2008) The RNA binding protein XSeb4R: a positive regulator of VegT mRNA stability and translation that is required for germ layer formation in Xenopus. GENE DEV, 22:2347-52
  Souopgui J, Rust B, Vanhomwegen J, Heasman J, Henningfeld KA, Bellefroid E, Pieler T
  
• (2009) Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. NEURON, 63: 628-42
  Poulopoulos A, Aramuni G, Meyer G, Soykan T, Hoon M, Papadopoulos T, Zhang M, Paarmann I, Fuchs C, Harvey K, Jedlicka P, Schwarzacher SW, Betz H, Harvey RJ, Brose N, Zhang W, Varoqueaux F
  
• (2009) PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts. DEV CELL, 16: 1-8
  Krahn MP, Egger-Adam D, Wodarz A
  
• (2009) Pre-fibrillar α–synuclein variants with impaired β–structure increase neurotoxicity in Parkinson`s disease models. EMBO J, 28: 3256-68
  Karpinar DP, Balija MB, Kügler S, Opazo F, Rezaei-Ghaleh N, Wender N, Kim HY, Taschenberger G, Falkenburger BH, Heise H, Kumar A, Riedel D, Fichtner L, Voigt A, Braus GH, Giller K, Becker S, Herzig A, Baldus M, Jäckle H, Eimer S, Schulz JB, Griesinger C, Zweckstetter M
  
• (2009) Tuning of synapse number, structure and function in the cochlea. NAT NEUROSCI, 12: 444-53
  Meyer AC, Frank T, Khimich D, Hoch G, Riedel D, Chapochnikov NM, Yarin YM, Harke B, Hell SW, Egner A, Moser T
  
• (2010) Bassoon and the synaptic ribbon organize Ca2+ channels and vesicles to add release sites and promote refilling. NEURON, 68: 724-38
  Frank T, Rutherford MA, Strenzke N, Neef A, Pangrsic T, Khimich D, Fetjova A, Gundelfinger ED, Liberman MC, Harke B, Bryan KE, Lee A, Egner A, Riedel D, Moser T
  
• (2010) Formation of a Bazooka/Stardust complex is essential for plasma membrane polarity in epithelia. J CELL BIOL, 190: 751-60
  Krahn MP, Bückers J, Kastrup L, Wodarz A
  
• (2010) Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells. NAT NEUROSCI, 13: 869-76
  Pangrsic T, Lasarow L, Reuter K, Takago H, Schwandner M, Riedel D, Frank T, Tarantino LM, Bailey JS, Strenzke N, et al. Moser T
  
• (2010) Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids. CURR BIOL, 20: 636-42
  Krahn MP, Klopfenstein D, Fischer N, Wodarz A
  
• (2010) Myelination and support of axonal integrity by glia. NATURE, 468(7321): 244-255. Review
  Nave KA
  
• (2010) Olfactory coding with patterns of response latencies. NEURON, 67: 872-84
  Junek S, Kludt E, Wolf F, Schild D
  
• (2010) Olfactory coding with patterns of response latencies. NEURON, 67: 872-84
  Junek S, Kludt E, Wolf F, Schild D
  
• (2010) Serotonin receptor 1A-modulated glycine receptor alpha 3 phosphorylation controls breathing in mice. J CLIN INV, 120: 4118-28
  Manzke T, Niebert M, Koch UR, Caley A, Vogelgesang S, Hülsmann S, Ponimaskin E, Müller U, Smart TG, Harvey RJ, Richter DW
  
• (2011) A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia. EMBO MOL MED, 3(6): 309-19
  Grube S, Gerchen MF, Adamcio B, Pardo LA, Martin S, Malzahn D, Papiol S, Begemann M, Ribbe K, Friedrichs H, Radyushkin KA, Müller M, Benseler F, Riggert J, Falkai P, Bickeböller H, Nave KA, Brose N, Stühmer W, Ehrenreich H.
  
• (2011) A readily retrievable pool of synaptic vesicles. NAT NEUROSCI, 14: 833-9
  Hua Y, Sinha R, Thiel CS, Schmidt R, Hüve J, Martens H, Hell SW, Egner A, Klingauf J
  
• (2011) A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching. NAT BIOTECHNOL, 29(19): 942-7
  Brakemann T, Stiel AC, Weber G, Andresen M, Testa I, Grotjohann T, Leutenegger M, Plessmann U, Urlaub H, Eggeling C, Wahl MC, Hell SW, Jakobs S
  
• (2011) Anatomical coupling of sensory and motor nerve trajectory through axon tracking. NEURON, 71: 263-277
  Wang L, Klein R, Zheng B, Marquardt T
  
• (2011) Dual-label STED nanoscopy of living cells using photochromism. NANO LETT, 11(9): 3970-3
  Willig KI, Stiel AC, Brakemann T, Jakobs S, Hell SW
  
• (2011) Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins. NAT NEUROSCI, 14: 411-3
  Nouvian R, Neef J, Bulankina AV, Reisinger E, Pangrsic T, Frank T, Sikorra S, Brose N, Binz T, Moser T
  
• (2011) Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells. NAT NEUROSCI, 14(9): 1109-11
  Gregory FD, Bryan KE, Pangršič T, Calin-Jageman IE, Moser T, Lee A
  
• (2011) Loss of the extraproteasomal ubiquitin receptor Rings lost impairs ring canal growth in Drosophila oogenesis. J CELL BIOL, 193: 71-80
  Morawe T, Honemann-Capito M, von Stein W, Wodarz A
  
• (2011) Sumoylation regulates alphasynucelin aggregation and toxicity. J CELL BIOL, 49-60
  Krumova P, Meulmeester E, Garrido M, Tirard M, Hsiao HH, Bossis G, Urlaub H, Zweckstetter M, Kügler S, Melchior F, Bähr M, Weishaupt JH
  
• (2012) 5-HT7R/G12 signaling regulates neuronal morphology and function in an age-dependent manner. J NEUROSCI, 32: 2915-2930
  Kobe F, Guseva D, Jensen TP, Wirth A, Renner U, Hess D, Müller M, Medrihan L, Zhang W, Zhang M, Braun K, Westerholz S, Herzog A, Radyushkin K, El-Kordi A, Ehrenreich H, Richter DW, Rusakov D, Ponimaskin E
  
• (2012) Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons. ACTA NEUROPATHOL, 123(5): 671-83
  Taschenberger G, Garrido M, Tereshchenko Y, Bähr M, Zweckstetter M, Kügler S
  
• (2012) Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature 485(7399): 517-521
  Fünfschilling U, Supplie LM, Mahad D, Boretius S, Saab AS, Edgar J, Brinkmann BG, Kassmann CM, Tzvetanova ID, Möbius W, Diaz F, Meijer D, Suter U, Hamprecht B, Sereda MW, Morales CT, Frahm, J, Goebbels S, Nave KA
  
• (2012) Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson’s disease. BRAIN, 135; 3355-3370
  Tönges L, Frank T, Tatenhorst L, Saal KA, Koch JC, Szego EM, Bähr M, Weishaupt JH, Lingor P
  
• (2012) Nanoscopy of Living Brain Slices with Low Light Levels. NEURON, 75(6): 992-1000
  Testa I, Urban NT, Jakobs S, Eggeling C, Willig KI, Hell SW
  
• (2012) Novel Red Fluorophores with superior performance in STED microscopy. OPTICAL NANOSCOPY, 1:7
  Wurm CA, Kolmakov K, Göttfert F, Ta H, Bossi M, Schill H, Berning S, Jakobs S, Donnert G, Belov VN, Hell SW
  
• (2012) rsEGFP2 enables fast RESOLFT nanoscopy of living cells. ELIFE, 1: e00248
  Grotjohann T, Testa I, Reuss M, Brakemann T, Eggeling C, Hell SW, Jakobs S
  
• (2013) A role for Schwann cell-derived neuregulin-1 in remyelination. NAT NEUROSCI, 16, 48-54
  Stassart RM, Fledrich R, Velanac V, Brinkmann BG, Schwab MH, Meijer D, Sereda MW, Nave KA
  
• (2013) Anle138b: a novel oligomer modulator for disease modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease. ACTA NEUROPATHOL, 125(6): 795-813
  Wagner J, Ryazanov S, Leonov A, Levin J, Shi S, Schmidt F, Prix C, Pan Montojo F, Bertsch U, Mitteregger Kretzschmar G, Geissen M, Eiden M, Leidel F, Hirschberger T, Deeg AA, Krauth JJ, Zinth W, Tavan P, Pilger J, Zweckstetter M, Frank T, Bähr M, Weishaupt JH, Uhr M, Urlaub H, Teichmann U, Samwer M, Bötzel K, Groschup M, Kretzschmar H, Griesinger C, Giese A
  
• (2013) Chromatin Regulation by BAF170 Controls Cerebral Cortical Size and Thickness. DEV CELL, 251-14
  Tuoc TC, Boretius S, Sansom SN, Pitulescu ME, Frahm J, Livesey FJ, Stoykova A
  
• (2013) Mapping remodeling of thalamo-cortical projections in the living reeler mouse brain by diffusion tractography. PROC NATL ACAD SCI USA, 110(19): E1797-806
  Harsan LA, Dávid C, Reisert M, Schnell S, Hennig J, von Elverfeldt D, Staiger JF
  
• (2013) Nanoscopy with more than 100.000 ‚doughnuts’. NAT METHODS, 10(8): 737-40
  Chmyrov A, Keller J, Grotjohann T, Ratz M, d’Este E, Jakobs S, Eggeling C, Hell SW
  
• (2013) Selective Presynaptic Enhancement of the prefrontal cortex to nucleus accumbens pathway by cocaine. PROC NATL ACAD SCI USA, 110: 713-8
  Suska A, Lee BR, Huang YH, Dong Y, Schlüter OM
  
• (2013) Structural basis of kynurenine 3-monooxygenase inhibition. NATURE, 496(7445): 382-5
  Amaral M, Levy C, Heyes DJ, Lafite P, Outeiro TF, Giorgini F, Leys D, Scrutton NS
  
• (2013) ß-synuclein aggregates and induces neurodegeneration in dopaminergic neurons. ANN NEUROL, 74(1): 109-18
  Taschenberger G, Toloe J, Tereshchenko J, Akerboom J, Wales P, Benz R, Becker S, Outeiro T, Looger L, Bähr M, Zweckstetter M, Kügler S
  
• (2014) Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. SCIENCE, 344(6187): 1023-1028
  Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Joo Koo S, Claßen GA, Krauss M, Haucke V, Urlaub H, Rizzoli SO
  
• (2014) Dlk1 promotes a fast motor neuron biophysical signature required for peak-force execution. SCIENCE, 343: 1264-1266
  Müller D, Cherukuri P, Henningfeld K, Poh CP, Wittler L, Grote P, Schlüter O, Schmidt J, Laborda J, Bauer SR, Brownstone RM, Marquardt T
  
• (2014) High-resolution mapping of intracellular fluctuations using carbon nanotubes. SCIENCE, 344(6187): 1031-1035
  Fakhri N, Wessel AD, Willms C, Pasquali M, Klopfenstein DR, MacKintosh FC, Schmidt CF
  
• (2014) Mild expression differences of MECP2 influencing aggressive social behavior. EMBO MOL MED, 6: 662-84
  Tantra M, Hammer C, Kästner A, Dahm L, Begemann M, Bodda C, Hammerschmidt K, Giegling I, Stepniak B, Castillo Venzor A, Konnte B, Erbaba B, Hartmann A, Tarami A, Schulz- Schaeffer W, Rujescu D, Mannan AU, Ehrenreich H
  
• (2014) Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. MOL PSYCHIATRY: (10): 1143-9
  Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Mohd Jofrry S, Gurvich A, Jensen N, Ostmeier K, Lühder F, Probst C, Martens H, Gillis M, Saher G, Assogna F, Spalletta G, Stöcker W, Schulz TF, Nave KA, Ehrenreich H
  
• (2014) Optogenetic stimulation of the auditory pathway. J CLIN INVEST, 124(3): 1114-29
  Hernandez VH, Gehrt A, Reuter K, Jing Z, Jeschke M, Mendoza Schulz A, Hoch G, Bartels M, Vogt G, Garnham CW, Yawo H, Fukazawa Y, Augustine GJ, Bamberg E, Kügler S, Salditt T, de Hoz L, Strenzke N, Moser T
  
• (2014) Site-Specific Labeling of RNA at Internal Ribose Hydroxyl Groups: Terbium-Assisted Deoxyribozymes at Work. J AM CHEM SOC, 136(22): 8131-7
  Büttner L, Javadi-Zarnaghi F, Höbartner C
  
• (2014) Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation. PLOS GENET, 10(11): e1004741
  Lazaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danz KM, Outeiro TF
  
• (2014) The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset. ACTA NEUROPATHOL, 127(5): 779-80
  Levin J, Schmidt F, Boehm C, Prix C, Bötzel K, Ryazanov S, Leonov A, Griesinger C, Giese A
  
• (2015) Durable protein lattices of clathrin that can be functionalized with nano-particles and active bio-molecules. NAT NANOTECHNOL, 10(11): 954-7
  Dannhauser PN, Platen M, Böning H, Schaap IAT
  
• (2015) Dynamic contact network between ribosomal subunits enables rapid large-scale rotation during spontaneous translocation. NUCLEIC ACIDS RES, 43: 6747-6760
  Bock LV, Blau C, Vaiana AC, Grubmüller H
  
• (2015) Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation. ACTA NEUROPATHOL, 129(5): 695-713
  Kunadt M, Eckermann K, Stuendl A, Gong J, Russo B, Strauss K, Rai S, Kügler S, Falomir Lockhart L, Schwalbe M, Krumova P, Oliveira LM, Bähr M, Möbius W, Levin J, Giese A, Kruse N, Mollenhauer B, Geiss-Friedlander R, Ludolph AC, Freischmidt A, Feiler MS, Danzer KM, Zweckstetter M, Jovin TM, Simons M, Weishaupt JH, Schneider A
  
• (2015) Induction of a-Synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies. BRAIN, 139(Pt2): 481-94
  Stuendl A, Kunadt M, Kruse N, Bartels C, Moebius W, Danzer KM, Mollenhauer B, Schneider A
  
• (2015) Modulation of Presynaptic Release Probability by the Vertebrate-Specific Protein Mover. NEURON, 87(3): 521-33
  Körber C, Horstmann H, Venkataramani V, Herrmannsdörfer F, Kremer T, Kaiser M, Schwenger DB, Ahmed S, Dean C, Dresbach T, Kuner T
  
• (2015) Perturbed Hippocampal Synaptic Inhibition and γ -Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism. CELL REP, 13(3): 516-523
  Hammer M, Krueger-Burg D, Tuffy LP, Cooper BH, Taschenberger H, Goswami SP, Ehrenreich H, Jonas P, Varoqueaux F, Rhee JS, Brose N
  
• (2015) Secondary-Ion Mass Spectrometry of Genetically Encoded Targets. ANGEW CHEM INT EDIT, 54(19): 5784-8
  Vreja IC, Kabatas S, Saka SK, Kröhnert K, Höschen C, Opazo F, Diederichsen U, Rizzoli SO
  
• (2015) Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies. ACS NANO, 9(11): 11034-41
  Vreja IC, Nikić I, Göttfert F, Bates M, Kröhnert K, Outeiro TF, Hell SW, Lemke EA, Rizzoli SO
  
• (2015) The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific Sulforhodamine 101-labeling of hippocampal astrocytes. BRAIN STRUCT FUNCT 220: 193-203
  Schnell C, Shahmoradi A, Wichert SP, Mayerl S, Hagos Y, Heuer H, Rossner MJ, Hülsmann S
  
• (2016) C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α -Synuclein in a Yeast Model of Parkinson's Disease. PLOS GENET, 12(6): e1006098
  Kleinknecht A, Popova B, Lázaro DF, Pinho R, Valerius O, Outeiro TF, Braus GH
  
• (2016) Cortical network dysfunction caused by a subtle defect of myelination. GLIA, 64(11): 2025-40
  Poggi G, Boretius S, Möbius W, Moschny N, Baudewig J, Ruhwedel T, Hassouna I, Wieser GL, Werner HB, Goebbels S, Nave KA, Ehrenreich H
  
• (2016) Environmental and genetic factors support the dissociation between alpha-synuclein aggregation and toxicity. PROC NATL ACAD SCI USA, 113(42): E6506-6515
  Villar-Piqué A, Lopes da Fonseca T, Sant'Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF
  
• (2016) Hair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes. PROC NATL ACAD SCI USA, 113(32): E4716-25
  Ohn TL, Rutherford MA, Jing Z, Jung S, Duque-Afonso CJ, Hoch G, Picher MM, Scharinger A, Strenzke N, Moser T
  
• (2016) Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism. NEURON, 91(1): 119-32
  Saab AS, Tzvetavona ID, Trevisiol A, Baltan S, Dibaj P, Kusch K, Möbius W, Goetze B, Jahn, HM, Huang W, Steffens H, Schomburg ED, Pérez-Samartín A, Pérez-Cerdá F, Bakhtiari D, Matute C, Löwel S, Griesinger C, Hirrlinger J, Kirchhoff F, Nave KA
  
• (2016) Redox-indicator mice stably expressing genetically-encoded neuronal roGFP: Versatile tools to decipher subcellular redox dynamics in neuropathophysiology. ANTIOXID REDOX SIGN, 25: 41-58
  Wagener KC, Kolbrink B, Dietrich K, Kizina KM, Terwitte LS, Kempkes B, Bao G, Müller M
  
• (2016) Single-vesicle imaging reveals different transport mechanisms between glutamatergic and GABAergic vesicles. SCIENCE, 351(6276): 981-4
  Farsi Z, Preobraschenski J, van den Bogaart G, Riedel D, Jahn R, Woehler A
  
• (2016) Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength. PROC NATL ACAD SCI USA, 113: E4548-E4557
  Taschenberger H, Woehler A & Neher E
  
• (2017) Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder. NAT COMMUN, 8: 818
  Huppke P, Weissbach S, Church JA, Schnur R, Krusen M, Dreha-Kulaczewski S, Kühn- Velten WN, Wolf A, Huppke B, Millan F, Begtrup A, Almusafri F, Thiele H, Altmüller J, Nürnberg P, Müller M, Gärtner J
  
• (2017) Adrenergic Gate Release for Spike Timing-Dependent Synaptic Potentiation. NEURON, 93: 394-408
  Liu Y, Cui L, Schwarz MK, Dong Y, Schlüter OM
  
• (2017) Dynamical sensitivity control of a single-spin quantum sensor. SCI REP, 7(1): 6586
  Lazariev A, Arroyo-Camejo S, Rahane G, Kavatamane VK, Balasubramanian G
  
• (2017) ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones. J CELL BIOL, 216: 1143- 1161
  Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, Rizzoli SO, Südhof TC, Rhee JS, Brose N
  
• (2017) Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release. NEURON, 94(2): 304-311
  Sigler A, Oh WC, Imig C, Altas B, Kawabe H, Cooper BH, Kwon HB, Rhee JS, Brose N
  
• (2017) Formation and maintenance of functional spines in the absence of presynaptic glutamate release. NEURON, 94: 304-311
  Sigler A, Oh WC, Imig C, Altas B, Kawabe H, Cooper BH, Kwon HB, Rhee JS, Brose N
  
• (2017) Glycation potentiates α-synucleinassociated neurodegeneration in synucleinopathies. BRAIN, 140(5): 1399-1419
  Vicente Miranda H, Szegő EM, Oliveira LM, Breda C, Darendelioglu E, Machado de Oliveira R, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Ferreira Rodrigues E, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Correia Santos N, Vaqueiro Lopes L, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF
  
• (2017) Kinetic requirements for spatiotemporal chemical imaging with fluorescent nanosensors, ACS NANO, 11(4): 4017-4027
  Meyer D, Hagemann A, Kruss S
  
• (2017) Rapid nonlinear image scanning microscopy. NAT METHODS, 14(11): 1087-89
  Gregor I, Spiecker M, Petrovsky R, Großhans J, Ros R, Enderlein J
  
• (2017) SK3 channel overexpression in mice causes hippocampal shrinkage associated with cognitive impairments. MOL NEUROBIOL, 54(2): 1078-91
  Martin S, Lazzarini M, Dullin C, Balakrishnan S, Gomes FV, Ninkovic M, El Hady A, Pardo, LA, Stühmer W, Del-Bel E
  
• (2017) Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder. J CLIN INVEST, 127(3): 1005-1018
  Lipstein N, Verhoeven-Duif NM, Michelassi FE, Calloway N, van Hasselt PM, Pienkowska K, van Haaften G, van Haelst MM, van Empelen R, Cuppen I, van Teeseling HC, Evelein AM, Vorstman JA, Thoms S, Jahn O, Duran KJ, Monroe GR, Ryan TA, Taschenberger H, Dittman JS, Rhee JS, Visser G, Jans JJ, Brose N
  
• (2017) The serotonin receptor subtype 5b specifically interacts with serotonin receptor subtype 1A. FRONT MOL NEURO- SCI, 10:299
  Niebert S, van Belle G, Vogelgesang S, Manzke T, Niebert M
  
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