Prebiotic scenarios for the origin of pyrimidine nucleosides and pairing systems

• Applicant: Professor Dr. Thomas Carell
• Subject Area: Biological and Biomimetic Chemistry
• Term: from 2016 to 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 326039064

We plan to extend the recently described präbiotically relevant FaPy-pathway (Science 2016) to the synthesis of naturally occurring non-canonical purine bases and pyrimidine as well as "pseudo-pyrimidine" bases. In addition, we propose the synthesis and investigation of novel amino acid RNA conjugates. The aim is to obtain a comprehensive picture of präbiotically relevant reaction pathways.

• DFG Programme: Research Grants