Project Details
Projekt
EXC 168: Regenerative Therapies - From Cells to Tissues to Therapies: Engineering the Cellular Basis of Regeneration
Subject Area
Medicine
Neurosciences
Neurosciences
Term
from 2006 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 32725986
An important goal of biomedical research for the 21st century is to understand how to exploit the regenerative capacity of the body for new therapies. Reconstructive therapy is already a reality for the transplantation of haematopoetic stem cells. However, for many major diseases such as diabetes, Morbus Parkinson, Alzheimer, bone/cartilage or myocardial diseases, regenerative therapy is still fiction. The Center for Regenerative Therapies Dresden (CRTD) integrates research in the field of nanotechnology, material science, medicine and biology in order to develope novel strategies for regenerative therapies.
Our main objectives are:
(1) to develop advanced regenerative therapies for haemato-oncological, endocrine, neurodegenerative, bone/cartilage and cardiovascular diseases,
(2) to study the crucial mechanisms controlling stem cell recruitment, activation, proliferation, and differentiation, in model organisms,
(3) to control these cellular processes using genetics, surface engineering, matrix engineering and microdevices in order to provide control of stem cell activity and regeneration,
(4) to test the novel regeneration therapies in pre-clinical and clinical trials,
(5) to develop such therapies into marketable products with our commercial partners,
(6) to develop a leading center for Regenerative Therapies in Europe.
The CRTD uses the financial support (cluster of excellence award) by the DFG to:
(1) catalyse the clinical translation of basic research results by creating dedicated clinical research positions,
(2) boost the application of new technologies in clinical and preclinical research through joint project funding, improved technology and facilitated technology transfer,
(3) strengthen materials sciences approaches by setting up a dedicated professorship in this area,
(4) create novel career options for junior researchers and support for female scientists.
Our main objectives are:
(1) to develop advanced regenerative therapies for haemato-oncological, endocrine, neurodegenerative, bone/cartilage and cardiovascular diseases,
(2) to study the crucial mechanisms controlling stem cell recruitment, activation, proliferation, and differentiation, in model organisms,
(3) to control these cellular processes using genetics, surface engineering, matrix engineering and microdevices in order to provide control of stem cell activity and regeneration,
(4) to test the novel regeneration therapies in pre-clinical and clinical trials,
(5) to develop such therapies into marketable products with our commercial partners,
(6) to develop a leading center for Regenerative Therapies in Europe.
The CRTD uses the financial support (cluster of excellence award) by the DFG to:
(1) catalyse the clinical translation of basic research results by creating dedicated clinical research positions,
(2) boost the application of new technologies in clinical and preclinical research through joint project funding, improved technology and facilitated technology transfer,
(3) strengthen materials sciences approaches by setting up a dedicated professorship in this area,
(4) create novel career options for junior researchers and support for female scientists.
DFG Programme
Clusters of Excellence
Applicant Institution
Technische Universität Dresden
Participating Institution
Max Bergmann Zentrum für Biomaterialien; Max-Planck-Institut für molekulare Zellbiologie und Genetik (MPI-CBG); Universitätsklinikum Carl Gustav Carus Dresden
Spokespersons
Professor Ezio Bonifacio, Ph.D., until 12/2018; Professor Dr. Michael Brand, from 11/2005 until 12/2020; Professor Dr. Federico Calegari, Ph.D., since 1/2021; Professorin Dr. Elly Margaret Tanaka, Ph.D., from 4/2014 until 5/2016
Participating Researchers
Dr. Christopher Antos; Professor Dr. Martin Bornhäuser; Professor Dr. Stefan R. Bornstein, Ph.D.; Professor Dr. Frank Buchholz; Professor Dr. Triantafyllos Chavakis; Professor Dr. Stefan Diez; Professor Dr. Gerhard Ehninger; Professor Dr. Michael Gelinsky; Professor Dr. Klaus-Peter Günther; Professor Dr. Lorenz C. Hofbauer; Professor Dr. Wieland B. Huttner; Professor Dr. Rolf Jessberger; Professor Dr. Gerd Kempermann; Professorin Dr. Elisabeth Knust; Professor Dr. Karsten Kretschmer; Professor Michele Solimena; Professor Dr. Adrian Francis Stewart; Professor Dr. Alexander Storch; Professor Dr. Torsten Tonn; Professorin Dr. Claudia Waskow; Professor Dr. Gilbert Weidinger; Professor Dr. Carsten Werner
