Molecular mechanisms of direct reprogramming of fibroblasts to trophoblast stem cells

• Applicants: Professor Dr. Hubert Schorle; Professor Dr. Joachim L. Schultze
• Subject Area: Reproductive Medicine, Urology ; General Genetics and Functional Genome Biology ; Bioinformatics and Theoretical Biology
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 329123747

• Final Report Year: 2022

Final Report Abstract

No abstract available

Publications

• (2018). Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming. Cell Stem Cell 1–23
  Schwarz, B.A., Cetinbas, M., Clement, K., Walsh, R.M., Cheloufi, S., Gu, H., Langkabel, J., Kamiya, A., Schorle, H., Meissner, A., Sadreyev, R.I., Hochedlinger, K.
  (See online at https://doi.org/10.1016/j.stem.2018.06.013)
• (2020). Choice of factors and medium impinge on success of ESC to TSC conversion. Placenta 90, 128–137
  Kaiser, F., Kubaczka, C., Graf, M., Langer, N., Langkabel, J., Arévalo, L., Schorle, H.
  (See online at https://doi.org/10.1016/j.placenta.2019.12.017)
• (2020). CRELD1 modulates homeostasis of the immune system in mice and humans. Nat Immunol 21, 1517-1527
  Bonaguro L, Köhne M, Schmidleithner L, Schulte-Schrepping J, Warnat-Herresthal S, Horne A, Kern P, Günther P, Ter Horst R, Jaeger M, Rahmouni S, Georges M, Falk CS, Li Y, Mass E, Beyer M, Joosten LAB, Netea MG, Ulas T, Schultze JL, Aschenbrenner AC
  (See online at https://doi.org/10.1038/s41590-020-00811-2)
• (2020). Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke. Nat Neurosci, 23, 351-362
  Werner Y, Mass E, Ashok Kumar P, Ulas T, Händler K, Horne A, Klee K, Lupp A, Schütz D, Saaber F, Redecker C, Schultze JL, Geissmann F, Stumm R
  (See online at https://doi.org/10.1038/s41593-020-0585-y)
• (2020). Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell 182, 1419-1440.e23
  Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE; Deutsche COVID-19 OMICS Initiative (DeCOI)
  (See online at https://doi.org/10.1016/j.cell.2020.08.001)
• (2021). COVID-19 and the human innate immune system. Cell 184, 1671-1692
  Schultze JL & Aschenbrenner AC
  (See online at https://doi.org/10.1016/j.cell.2021.02.029)
• (2021). Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients. Genome Med 13, 7
  Aschenbrenner AC, Mouktaroudi M, Krämer B, Oestreich M, Antonakos N, Nuesch-Germano M, Gkizeli K, Bonaguro L, Reusch N, Baßler K, Saridaki M, Knoll R, Pecht T, Kapellos TS, Doulou S, Kröger C, Herbert M, Holsten L, Horne A, Gemünd ID, Rovina N, Agrawal S, Dahm K, van Uelft M, Drews A, Lenkeit L, Bruse N, Gerretsen J, Gierlich J, Becker M, Händler K, Kraut M, Theis H, Mengiste S, De Domenico E, Schulte-Schrepping J, Seep L, Raabe J, Hoffmeister C, ToVinh M, Keitel V, Rieke G, Talevi V, Skowasch D, Aziz NA, Pickkers P, van de Veerdonk FL, Netea MG, Schultze JL, Kox M, Breteler MMB, Nattermann J, Koutsoukou A, Giamarellos-Bourboulis EJ, Ulas T; German COVID-19 Omics Initiative (DeCOI)
  (See online at https://doi.org/10.1186/s13073-020-00823-5)
• (2021). Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs. Nat Commun 12, 7322
  Langkabel, J., Horne, A., Bonaguro, L., Holsten, L., Hesse, T., Knaus, A., Riedel, Y., Becker, M., Händler, K., Elmzzahi, T., Bassler, K., Reusch, N., Yeghiazarian, L.H., Pecht, T., Saglam, A., Ulas, T., Aschenbrenner, A.C., Kaiser, F., Kubaczka, C., Schultze, J.L., Schorle, H.
  (See online at https://doi.org/10.1038/s41467-021-27586-w)