Project Details
Projekt
Impact of chronic IFN-I signalling in liver fibrosis on anti-viral immunity ((2)-P32*)
Subject Area
Rheumatology
Term
from 2017 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 36842431
The underlying cellular and molecular factors for the enhanced susceptibility of patients with liver fibrosis to viral and bacterial infections are unclear. Recently, we found that translocation of gut microbiota induces chronic IFN-I expression, which hampers viral clearance in a preliminary experiments. In this project, we aim to explore the cellular and molecular mechanisms by which IFN-I might affect the function of key players of anti-viral immunity i.e. antigen presenting cells, CD4 T and CD8 T cells in liver fibrosis and how this may perpetuate and accelerate the fibrogenic process. The results of this project will enhance our understanding of impaired cellular immunity in patients with liver fibrosis, aggravation of liver fibrosis by persistent infection and potentially open new venues for therapeutic and vaccination approaches.
DFG Programme
CRC/Transregios
Applicant Institution
Rheinisch-Westfälische Technische Hochschule Aachen
Project Head
Professorin Dr. Zeinab Abdullah
