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Prokaryotic to plant phytochrome function (B08*)

Subject Area Plant Biochemistry and Biophysics
Biophysics
Term from 2017 to 2020
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 221545957
 
We propose to extend our phytochrome structure/function studies from the cyanobacterial phytochrome Cph1 to plant phytochromes, as these connect to entirely different cellular signaling pathways. The role of protonation dynamics and structural changes during Pr↔Pfr photoconversion will be studied by X-ray and neutron crystallography, solid-state NMR and surface labeling methods to monitor proton release and domain shifts, whereby mutants will provide access to experimental manipulation of the molecular signaling mechanism.
DFG Programme Collaborative Research Centres
Applicant Institution Freie Universität Berlin
Project Head Professor Dr. Jonathan Hughes, Ph.D., since 1/2017
 
 

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