Role of the phospholipid hydroxyperoxide glutathion peroxidase (PHGPx) GPx4 in murine hepatozytes and hepatocarcinogenesis (A22*)

• Subject Area: Gastroenterology
• Term: from 2017 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 61867463

Glutathion-Peroxidase 4 is part of the anti-oxidant system of the cell and a loss can trigger a specific form of cell death, namely ferroptosis. Aim of this new project is the investigation of role of GPx4 in the liver using hepatocyte specific GPx4 knockout mice. Another focus lies on investigating the GPx4-dependent ferroptosis in transposon based models of hepatocarcinogenesis and non-alcoholic steatoheapatitis (NASH) using suitable genetic mouse models.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 815: Redox-Regulation: Generating Systems and Functional Consequences
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Co-Applicant Institution: Georg-Speyer-Haus; Institut für Tumorbiologie und experimentelle Therapie
• Project Head: Professor Dr. Florian R. Greten