The photopic negative response as a biomarker for functional integrity of the optic nerve

• Applicant: Professor Dr. Jan Kremers
• Subject Area: Ophthalmology
• Term: from 2007 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 34425406

• Final Report Year: 2014

Final Report Abstract

The results of the experiments that were performed in the frame of this project showed that: a) The Addition of On- and Off responses are not homologous to the pattern ERG. Different processes and mechanisms probably play a role. The ideas of the origins of the pattern ERGs need to be revisited. b) As a result, the On-Off-additions may provide additional and independent parameter for detection, diagnosis and monitoring of glaucoma. c) The cone input to the On- and Off-ERGs show that cone opponent mechanisms play a major role in the generation of the ERG. Textbook knowledge so far did not take this into account and therefore should be revised.

Publications

• (2010): Flicker ERGs representing chromaticity and luminance signals. Investigative Ophthalmol Vis Sci., 51: 577-587
  J. Kremers, A.R. Rodrigues, L.C.L. Silveira, M. da Silva Filho
  
• (2011): Heterochromatic flicker electroretinograms reflecting luminance and cone opponent activity in glaucoma patients. Investigative Ophthalmol Vis Sci., 52: 6757-6765
  M.T.S. Barboni, G. Pangeni, D.F. Ventura, F.K. Horn, J. Kremers
  
• (2012): ERG responses to photoreceptor specific sine wave modulation. J. Opt. Soc. Am. A, 29: A309-A316
  J. Kremers, G. Pangeni
  
• (2012): On- and Off- response ERGs elicited by sawtooth stimuli in normal subjects and glaucoma patients. Doc Ophthalmol., 124: 237-248
  G. Pangeni, R. Lämmer, R.P. Tornow, F.K. Horn, J. Kremers
  
• (2012): Spectral characteristics of the PhNR in the full field flash electroretinogram of normals and glaucoma patients. Doc Ophthalmol., 124: 79–90
  J. Kremers, M. Jertila, B. Link, G. Pangeni, F.K. Horn
  
• (2014): Incremental and decremental L- and M-cone driven ERG responses: II. Sawtooth stimulation. J. Opt. Soc. Am. A, 31: A170-A178
  J. Kremers, G. Pangeni, K.T. Tsaousis, D. McKeefry, I.J. Murray, N.R.A. Parry