Computational Multiphysics Modeling of the Postprandial Human Stomach
Final Report Abstract
Health problems related to the mechanics of the stomach (gastric mechanics) are among the most important causes of morbidity in industrialized countries. For example, around 10% - 20% of the population in Western countries suffers from gastro-esophageal reflux disease (GERD). Around 10% - 45% of the general population suffers from dyspepsia, that is, difficult digestion, which is often linked to the motility of the stomach. Altogether, healthcare costs related to the stomach and gastrointestinal tract are roughly comparable to the ones associated with cardiovascular diseases. Interestingly, this tremendous importance of the stomach is not at all reflected by current research efforts in biomechanics. Much more modeling work is dedicated to modeling of the cardiovascular system than to the stomach. In fact, so far only a very limited number of papers focuses on computational modeling of the stomach. This project aimed at closing this important gap in biomechanical research by developing a computational multi-physics model of the human stomach. The computational model developed in this project is intended to provide a valuable basis for future research projects examining the link between gastric mechanics and disorders and pathologies like dyspepsia, gastro-esophageal reflux disease, or morbid obesity.
Publications
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Computational model of gastric motility with active‐strain electromechanics. ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik, 98(12), 2177-2197.
Brandstaeter, Sebastian; Gizzi, Alessio; Fuchs, Sebastian L.; Gebauer, Amadeus M.; Aydin, Roland C. & Cyron, Christian J.
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Active-strain electromechanics for the computational modeling of gastric peristalsis, 25th Congress of the European Society of Biomechanics, Vienna, Austria, July 7 – 10
Brandstaeter S., Gizzi A., Fuchs S.L., Aydin R.C. & Cyron C.J.
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Active-strain electromechanics for the computational modeling of gastric peristalsis, 90th Annual Meeting of the International Association of Applied Mathematics and Mechanics, Vienna, Austria, February 18 – 22
Brandstaeter S., Fuchs S.L., Gizzi A., Aydin R.C. & Cyron C.J.
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Mechanics of the stomach: A review of an emerging field of biomechanics. GAMM-Mitteilungen, 42(3).
Brandstaeter, Sebastian; Fuchs, Sebastian L.; Aydin, Roland C. & Cyron, Christian J.
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Computational modeling of the stomach, GACM Report, winter, 13: 34 – 39
Miftahof R.N., Brandstaeter S., Fuchs S. & Cyron C.J.
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A novel smoothed particle hydrodynamics and finite element coupling scheme for fluid–structure interaction: The sliding boundary particle approach. Computer Methods in Applied Mechanics and Engineering, 383, 113922.
Fuchs, Sebastian L.; Meier, Christoph; Wall, Wolfgang A. & Cyron, Christian J.
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An SPH framework for fluid–solid and contact interaction problems including thermo-mechanical coupling and reversible phase transitions. Advanced Modeling and Simulation in Engineering Sciences, 8(1).
Fuchs, Sebastian L.; Meier, Christoph; Wall, Wolfgang A. & Cyron, Christian J.
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Dirichlet-Neumann partitioned fluid-structure interaction using SPH and FEM, 14th World Congress in Computational Mechanics, Paris, France, January 11 – 15
Fuchs S.L., Meier C., Wall W.A. & Cyron C.J.
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Gastric peristalsis: a computational framework based on active-strain electromechanics, 14th World Congress in Computational Mechanics, Paris, France, January 11 – 15
Brandstaeter S., Fuchs S.L., Gizzi A., Aydin R.C. & Cyron C.J.
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Patient-specific modelling of gastric peristalsis, 10th GACM Colloquium on Computational Mechanics, Vienna, Austria, September 10 – 13
Henke M.S., Brandstaeter S., Fuchs S.L., Schäfer P.M., Aydin R.C. & Cyron C.J.
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Computational modelling of the stomach with patient-specific geometries, 9th European Congress on Computational Methods in Applied Sciences and Engineering, Lisbon, Portugal, June 3 – 7
Henke M.S., Brandstaeter S., Fuchs S.L. & Cyron C.J.
