Corticosteroid Receptor-Mediated Control of Endocrine Adipocyte Function

• Applicant: Professor Dr. Johannes Klein
• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2006 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 35305916

• Final Report Year: 2012

Final Report Abstract

No abstract available

Publications

• Direct adipotropic actions of aton/astatin: Differentiation state-dependent induction of apoptosis, modulation of endocrine function, and inhibition of glucose uptake. EurJ Pharmacol (2007) 564:37-46
  Mauser W, Penwitz N, Meier B, Fasshauer M, Klein J
  
• What are subcutaneous adipocytes really good for? (2007) Exp. Dermatol. 16:45-70
  Klein J, Fasshauer M
  
• Expression of ATRAP in adipocytes and negative regulation by beta3-adrenergic Stimulation of JAK/STAT. (2008) Horm Metab Res. Mar; 10(3):165-71
  Westphal S, PenAritz N, Iwen A, Kraus D, Fasshauer M, Klein J
  
• Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a pro-inflammatory adipokine profile, and stimulates UCP-1 in adipocytes. J Endocrinol. (2008) Mar; 196(3):465-72
  Iwen KAH, Senyaman Ö, Schwartz A, Drenckhan M, Meier B, Hadaschik D, Klein J
  
• Therapiemöglichkeiten der Adipositas, Med. Welt (2008) 1/2 (59):18-22
  Iwen KAH, Klein J.
  
• 40-year-old patient with newly diagnosed diabetes mellitus and progressive migraine attacks. Dtsch. Med. Wochenschr. (2009) 134:307-308
  Iwen KAH, Pais 1, Klein J, Lehnert H
  
• Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1 alpha. J Biol Chem Nov () 20;284:328l3-26
  Zhang Y, Huypens P, Adamson AW, Chang JS, Henaganl TM, Lenardl NR, Burk D, Klein J, Perwitz N, Shin J, Fasshauer M, Kralli A, Gettys TW
  
• Depot-specific adipocyte cell lines reveal differential drug-induced responses of white adipocytes - relevance for partial lipodystrophy. Am J Physiol Endocrinol. Metab. () 269:E315-322
  Kovsan J, Osnis A, Maissel A, Mazor L, Tamovscki T, Hollander L, Ovaia S, Meier B, Klein J, Bashan N, Rudich A.
  
• Arginine-vasopression directly promotes a thermogenic and pro-inflammatory adipokine expression profile in brown adipocytes. Regul. Peptides (2010) Sep 24; 164(2-3): 126-32
  Küchler S, Perwitz N, Schick RR, Klein J, Westphal S.
  
• Cannabionoid 1 receptor blockade induces transdifferentiation towards an insulin-sensitive brown fat phenotype in white adipocytes. (2010) Diabetes, Obes. & Metab. (2010) 12: 158-66
  Perwitz N, Wenzel J, Wagner 1, Büning J, Drenckhan M, Zarse K, Ristow M, Lilienthal W, Lehnert H, Klein J.
  
• The balance between gluco- and mineralo-corticoid action critically determines inflammatory adipocyte responses. J. Endocrinol. (2010) 204:153-64
  Hoppmann J, Perwitz N, Meier B, Fasshauer M, Hadaschik D, Lehnert H, Klein J.
  
• Cannabinoid type 1 receptor mediates depot-specific effects on differentiation, inflammation and oxidative metabolism in inguinal and epididymal white adipocytes. Nutrition and Diabetes (2011) 1, e16;doi:10.1038/nutd.2011.12 Published online 5 September
  Wagner I, Perwitz N, Drenckhan M, Lehnert H, Klein J.
  (See online at https://doi.org/10.1038/nutd.2011.12)
• Coldinduced alteration of adipokine profile in humans. Metabolism (2011) Mar; 60(3): 430-7
  Iwen KA, Wenzel ET, Ott V, Penwitz N, Wellhöner P, Lehnert H, DodtC, Klein J.
  
• Overweight. A valid predictor of cardiometat)olic risk? Internist (Berl). (2011) Apr; 52(4)352:354-6,358
  Iwen KA, Perwitz N, Lehnert H, Klein J.