Cold atmospheric plasmas for the study of fundamental interaction mechanisms with biological substrates: the role of ions and the plasma-induced liquid chemistry
Final Report Abstract
The project “Cold atmospheric plasmas for the study of fundamental interaction mechanisms with biological substrates: the role of ions and the plasma induced liquid chemistry” aimed for a better understanding of the interplay of cold physical plasmas with surfaces relevant for biomedical applications. Till today this interplay is poorly understood, especially if humidity or a liquid surface, which is usually always present for biological materials, are involved in the ongoing plasma-surface processes. Furthermore, a plasma consists of multiple species such as ions, electrons, and photons, therefore, knowledge about the effects induced by only one of these species is quite limited and hard to obtain. To tackle these issues two pathways were taken. First, the chemistry in the liquid treated by an effluent of a cold atmospheric pressure plasma jet, the so-called COST-jet, is investigated by experiments and simulations. It could be shown that the reactions of plasma generated atomic oxygen at the liquid surface with organic compounds are dominating compared its reactions in the liquid bulk. Therefore, characteristics of the treated species (such as being a surfactant) and/or mixing of the liquid play a significant role for the effective plasma treatment of liquids. Furthermore, the combination of experiments and simulations allowed to validate approximations of till today unknown values such as the Henry’s law solubility constant for atomic oxygen. Second, the isolated effect of ions onto biological substrates and for thin film growth were investigated. A major challenge is the generation of isolated ions at atmospheric pressure. A novel vacuum-UV-photoionization chamber was developed that utilizes plasma-generated VUV radiation to ionize neutral gas, and in which the generated ions are used to the substrate to be treated or for diagnosis. The gas flow rates and chamber geometry were optimized in advance with fluid flow simulations. A moderate electric field was used and also optimized by simulations to drag the ions homogeneously towards the substrate. Spatially resolved current and mass spectrometry measurements revealed significant ion fluxes which agree with the electric field profiles found in the simulations. Admixture of precursor gases such as acetylene resulted in ion-based deposition of amorphous carbon films. Therefore, the newly developed VUV-photoionization chamber fulfills all requirements to study the isolated ion-surface interaction under atmospheric pressure conditions and will be used to do so in the near future for biological substrates as well.
Publications
-
Characterization of isolated and combined radical, photon, and ion effects of cold atmospheric plasmas on liquids, 71. GEC, Portland, Oregon, USA – talk
J. Benedikt, K. Sgonina, J. Golda, G. Willems, M. Mokhtar Hefny & B. Biskup
-
Cold atmospheric plasma interaction with liquids and biological substrates: characterization of isolated and combined radical, photon, and ion effects, SPPT Prague, Czech Republic – talk
J. Benedikt, K. Sgonina, J. Golda, G. Willems, M. Mokhtar Hefny, B. Biskup, P. Vogel & C. Karczewski
-
Diagnostics and application of reactivity of atmospheric plasmas in studies relevant for plasma medicine, 82th DPG spring meeting, Erlangen, Germany – talk
J. Benedikt, M. Mokhtar Hefny, G. Willems, P. Vogel, C. Karczewski, J. Bandow & P. Lukes
-
Investigation of the Isolated Ion Interaction with Biological Substrates and Liquids, International Conference on Plasma Medicine, Philadelphia, USA – poster; awarded with “The Best student paper award”
K. Sgonina, P. Vogel, C. Karczewski, A. Giardina, J. Bandow & J. Benedikt
-
Investigation of the Role of Atomic Oxygen in Water Using an Atmospheric Pressure Plasma Jet, Young Professionals Workshop on Plasma Medicine – Frontiers in Redox Biochemistry and Medicine, Rostock, Germany – talk
K. Sgonina, M. Mokhtar Hefny, N. Dose & J. Benedikt
-
Reactivity transfer from atmospheric plasmas to solid surfaces and liquids, GRC Plasma Processing Science conference, Smithfield, Rhode Island, USA – poster
J. Benedikt, M. Mokhtar Hefny, K. Sgonina, D. Necas, L. Zajickova & J. Golda
-
The fate of plasma-generated oxygen atoms in aqueous solutions: non-equilibrium atmospheric pressure plasmas as an efficient source of atomic O(aq). Physical Chemistry Chemical Physics, 20(17), 12037-12042.
Benedikt, J.; Mokhtar, Hefny M.; Shaw, A.; Buckley, B. R.; Iza, F.; Schäkermann, S. & Bandow, J. E.
-
Interaction of plasma-generated reactive species with aqueous solutions, International Symposium on Plasma Chemistry, Neaples, Italy – poster
K. Sgonina, G. Bruno, N. Dose, K. Wende & J. Benedikt
-
Interaction of plasma-generated reactive species with methylene blue, DPG spring meeting, Munich, Germany – poster
K. Sgonina, N. Dose & J. Benedikt
-
Loss processes of plasma-generated atomic oxygen in a phenol solution, Plasma - BioMed - Workshop, Neumünster, Germany – talk
K. Sgonina, G. Bruno, K. Wende & J. Benedikt
-
Mass spectrometry and plasma chemistry of atmospheric pressure plasma jets, ICPIC, Sapporo, Japan – general invited talk
J. Benedikt, K. Sgonina, G. Willems, S. Große-Kreul, M. Mokhtar Hefny, S. Schneider & D. Ellerweg
-
Vorteile und Herausforderungen der ADP in Anwendungen, AK-ADP Workshop, Kiel, Germany – talk
J. Benedikt, J. Golda, K. Sgonina, N. Dose, O. Hansen, B. Biskup & M. Mokhtar Hefny
-
Mass spectrometry of neutrals and positive ions in He/CO2 non-equilibrium atmospheric plasma jet. Plasma Physics and Controlled Fusion, 62(3), 034005.
Willems, Gert; Hecimovic, Ante; Sgonina, Kerstin; Carbone, Emile & Benedikt, Jan
-
Treating Surfaces with a Cold Atmospheric Pressure Plasma using the COST-Jet. Journal of Visualized Experiments(165).
Golda, Judith; Sgonina, Kerstin; Held, Julian; Benedikt, Jan & Schulz-von, der Gathen Volker
-
Vacuum ultraviolet spectroscopy of cold atmospheric pressure plasma jets. Plasma Processes and Polymers, 17(6).
Golda, Judith; Biskup, Beatrix; Layes, Vincent; Winzer, Tristan & Benedikt, Jan
-
Experimental and modeling study of surface reactions of plasma generated atomic oxygen with phenol solutions, Symposium on Application of Plasma Processes, virtual – talk
K. Sgonina, G. Bruno, K. Wende & J. Benedikt
-
Loss processes of plasma generated atomic oxygen in phenol solutions, DPG SMuK conference, virtual – talk
K. Sgonina, G. Bruno, S. Wyprich, K. Wende & Jan Benedikt
-
Reactions of plasma-generated atomic oxygen at the surface of aqueous phenol solution: Experimental and modeling study. Journal of Applied Physics, 130(4).
Sgonina, K.; Bruno, G.; Wyprich, S.; Wende, K. & Benedikt, J.
-
Reactions of Plasma-Generated Atomic Oxygen with Phenol Solutions, International Conference on Plasma Medicine, virtual – talk
K. Sgonina, G. Bruno, S. Wyprich, K. Wende & Jan Benedikt
-
VUV-Photoionisation Chamber for the Characterization of Ion-Substrate Interactions at Atmospheric Pressure, Gaseous Electronics Conference, virtual – talk
K. Sgonina, A. Quack, C. Schulze, T. Winzer, L. Mohn & J. Benedikt
-
Selective study of ion-substrate interactions using the VUV-photoionization chamber, Central European Symposium on Plasma Chemistry, Štrbské Pleso, Slovakia – talk; awarded with the ”Young scientist prize for the best oral presentation”
K. Sgonina, A. Quack, C. Schulze & J. Benedikt
-
VUV photoionization chamber: study of ion interaction with substrates at atmospheric pressure, Erfahrungsaustausch Oberflächentechnologie mit Plasma- und Ionenstrahlprozessen, Mühlleithen, Germany – talk
K. Sgonina, A. Quack, C. Schulze & J. Benedikt
-
VUV-photoionization chamber for the selective study of ion-substrate interactions, DPG spring meeting, virtual – talk
K. Sgonina, A. Quack, C. Schulze & J. Benedikt
