Regulation of proteasome modules (B03)

• Subject Area: Biochemistry
• Term: from 2007 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 25065445

Project B03 aims to investigate the modes of proteasome biogenesis, which are important to form different functional multi-subunit proteasome modules in mammalian cells. In the next grant period this project will proceed with the in vitro and in vivo analyses of proteasome assembly steps including determinants of translational control of proteasomes. Furthermore, the project will extend the studies on structure and function relationships using the different proteasome mutations found in patients and in terms of association of regulator particles on the proteasome core complex.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 740: From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Peter Michael Kloetzel, until 12/2014; Professorin Dr. Elke Beate Krüger