Modulare Organisation der Vesikelanheftung an Membranen: Analyse struktureller Eigenschaften und Regulation durch Proteinpalmitoylierung (C01)

Vesicular transport in eukaryotic cells underlies a modular organization with defined submodular activities that are functionally conserved for each transport process, irrespective of donor and target membrane. In previous work, we have initiated a structural and biochemical characterization of the multi-subunit tethering complex TRAPP (transport protein particle) and its regulation by protein palmitoylation. It is proposed to extend these studies towards a comprehensive description of the three-dimensional structure, assembly and function of TRAPP which may serve as a paradigm for tethering complexes in vesicle transport in general.

DFG-Verfahren Sonderforschungsbereiche

Teilprojekt zu SFB 740:  Von Molekülen zu Modulen: Organisation und Dynamik zellulärer Funktionseinheiten

Antragstellende Institution Gemeinsam FU Berlin und HU Berlin durch:
Charité - Universitätsmedizin Berlin

Mitantragstellende Institution Freie Universität Berlin; Max-Delbrück-Centrum für Molekulare Medizin (MDC)

Teilprojektleiter Professor Dr. Udo Heinemann; Privatdozent Dr. Michael Veit