Project Details
Neuronal regulation of glutamate homeostasis in addictive behavior
Applicant
Theresa Rimmele, Ph.D.
Subject Area
Molecular Biology and Physiology of Neurons and Glial Cells
Term
from 2017 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 364631096
Glutamate homeostasis−the control of glutamate in and around synapses, has been shown to be critical in regulating addictive behavior. It has been assumed that astrocytes play the dominant role in determining glutamate homeostasis. Using a conditional knockout in the glutamate transporter GLT-1, the major glutamate transporter in the brain, we have found that inactivating GLT-1 in neurons has a significant impact on the effects of the psychostimulant amphetamine. These results suggest that neuronal control of glutamate homeostasis is a critical factor in psychostimulant addiction. The study aims to characterize the described phenomenon in more detail and investigate the underlying mechanisms using behavioral, molecular biology and fluorescence imaging approaches.
DFG Programme
Research Fellowships
International Connection
USA