Characterization of the human NoCut pathway

• Antragsteller: Dr. Patrick Steigemann
• Fachliche Zuordnung: Zellbiologie
• Förderung: Förderung von 2006 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 36514477

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Dividing cells need to first segregate the complete set of replicated chromosomes and then split into two daughter cells by a process termed cytokinetis. Failures in cytokinesis result in a tetraploid state with supernumerary copy numbers of chromosomes. This can lead to abnormal cell proliferation and is suspected to promote cancerogenesis. We identified a new celt division control mechanism in human cells that coordinates the timing of chromosome segregation and the last step of cytokinetis, abscission. This mechanism protects cells with delayed chromosome segregation against tetraploidization.

Projektbezogene Publikationen (Auswahl)

• Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidizati on, Cell (2009)
  Steigemann et al.
  (Siehe online unter https://doi.org/10.1016/j.cell.2008.12.020)