Die Rolle von RhoH und anderen Mitgliedern der Rho GTPase-Familie in der Entwicklung und Progression der chronischen lymphatischen Leukämie der B-Zell-Reihe (B-CLL)

• Applicant: Dr. Ina Rattmann
• Subject Area: Hematology, Oncology
• Term: from 2006 to 2008
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 36535080

• Final Report Year: 2008

Final Report Abstract

In summary the data strongly suggest that RhoH plays a role in the progression of the B-CLL-like disease in the transgenic Eμ-TCL1 mouse model. This will allow detailed molecular studies of the role of RhoH in pathways altered in TCL1-induced expansion of B-cell precursor populations in this model.

Publications

• The expression of the GTPase-Deficient, hematopoietic-specific RhoH GTPase Is Implicated in Development of Chronic Lymphocytic Leukemia (CLL). Blood, Volume 110, Issue 11, Abstr. 339
  Rattmann I, Zhu D, Croce CM, Byrd J, Gu Y, Moritz T, Williams DA