TRR 240:  Platelets – Molecular, cellular and systemic functions in health and disease

• Subject Area: Biology ; Medicine
• Term: from 2018 to 2023
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 374031971

• Final Report Year: 2023

Final Report Abstract

Besides their central role in haemostasis and thrombosis, platelets are increasingly recognised as versatile effector cells in inflammation, the innate and adaptive immune response, extracellular matrix reorganisation and fibrosis, maintenance of barrier and organ integrity, and host response to pathogens. These platelet functions, referred to as thrombo-inflammation and immunothrombosis, have gained major attention in the COVID-19 pandemic, where patients develop an inflammatory disease state with severe and life-threatening thromboembolic complications. In the CRC/TR 240, a highly interdisciplinary team of basic, translational and clinical scientists explored these emerging roles of platelets with the aim to develop novel treatment concepts for cardiovascular disorders and beyond. We have i) unravelled mechanisms leading to life-threatening thromboembolic complications following vaccination against SARS-CoV-2 with adenoviral vector-based vaccines, ii) identified unrecognised functions of platelet receptors and their regulation, offering new potential targets for pharmacological intervention and iii) developed new methodology to study the biology of megakaryocytes (MKs), the precursor cells of platelets in the bone marrow, which lay the foundation for the modulation of platelet biogenesis and function. The projects of the CRC/TR 240 built on the unique expertise of our research network and focussed on the following complementary fields: (A) Cell biology of megakaryocytes and platelets and (B) Platelets as regulators and effectors in disease. To achieve this aim, we followed a comprehensive approach starting out from in vitro systems and animal models to clinical research with large prospective patient cohorts and data-/biobanking. Despite the comparably short funding period the CRC/TR 240 discovered basic new mechanisms of platelet biogenesis, signal transduction and effector function and identified potential MK/plateletspecific molecular targets for diagnosis and therapy of thrombotic, haemorrhagic and thrombo-inflammatory disease states.

Publications

• A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis. Nature Communications, 9(1).
  Wen, Lai; Feil, Susanne; Wolters, Markus; Thunemann, Martin; Regler, Frank; Schmidt, Kjestine; Friebe, Andreas; Olbrich, Marcus; Langer, Harald; Gawaz, Meinrad; de Wit, Cor & Feil, Robert
  
• Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis. Circulation, 138(16), 1720-1735.
  Sauter, Reinhard J.; Sauter, Manuela; Reis, Edimara S.; Emschermann, Frederic N.; Nording, Henry; Ebenhöch, Sonja; Kraft, Peter; Münzer, Patrick; Mauler, Maximilian; Rheinlaender, Johannes; Madlung, Johannes; Edlich, Frank; Schäffer, Tilman E.; Meuth, Sven G.; Duerschmied, Daniel; Geisler, Tobias; Borst, Oliver; Gawaz, Meinrad; Kleinschnitz, Christoph ... & Langer, Harald F.
  
• Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome. Blood, 132(5), e1-e12.
  Peng, Bing; Geue, Sascha; Coman, Cristina; Münzer, Patrick; Kopczynski, Dominik; Has, Canan; Hoffmann, Nils; Manke, Mailin-Christin; Lang, Florian; Sickmann, Albert; Gawaz, Meinrad; Borst, Oliver & Ahrends, Robert
  
• Loss of CXCR4 on non-classical monocytes in participants of the Women’s Interagency HIV Study (WIHS) with subclinical atherosclerosis. Cardiovascular Research, 115(6), 1029-1040.
  Mueller, Karin A. L.; Hanna, David B.; Ehinger, Erik; Xue, Xiaonan; Baas, Livia; Gawaz, Meinrad P.; Geisler, Tobias; Anastos, Kathryn; Cohen, Mardge H.; Gange, Stephen J.; Heath, Sonya L.; Lazar, Jason M.; Liu, Chenglong; Mack, Wendy J.; Ofotokun, Igho; Tien, Phyllis C.; Hodis, Howard N.; Landay, Alan L.; Kaplan, Robert C. & Ley, Klaus
  
• Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis. Circulation Research, 122(12), 1661-1674.
  Cochain, Clément; Vafadarnejad, Ehsan; Arampatzi, Panagiota; Pelisek, Jaroslav; Winkels, Holger; Ley, Klaus; Wolf, Dennis; Saliba, Antoine-Emmanuel & Zernecke, Alma
  
• Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: a multicentre, open-label, randomised superiority trial. The Lancet, 392(10151), 940-949.
  Vranckx, Pascal; Valgimigli, Marco; Jüni, Peter; Hamm, Christian; Steg, Philippe Gabriel; Heg, Dik; van, Es Gerrit Anne; McFadden, Eugene P.; Onuma, Yoshinobu; van Meijeren, Cokky; Chichareon, Ply; Benit, Edouard; Möllmann, Helge; Janssens, Luc; Ferrario, Maurizio; Moschovitis, Aris; Zurakowski, Aleksander; Dominici, Marcello; Van, Geuns Robert Jan ... & Zweiker, Robert
  
• Analyzing pharmacological intervention points: A method to calculate external stimuli to switch between steady states in regulatory networks. PLOS Computational Biology, 15(7), e1007075.
  Breitenbach, Tim; Liang, Chunguang; Beyersdorf, Niklas & Dandekar, Thomas
  
• Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation. New England Journal of Medicine, 380(16), 1509-1524.
  Lopes, Renato D.; Heizer, Gretchen; Aronson, Ronald; Vora, Amit N.; Massaro, Tyler; Mehran, Roxana; Goodman, Shaun G.; Windecker, Stephan; Darius, Harald; Li, Jia; Averkov, Oleg; Bahit, M. Cecilia; Berwanger, Otavio; Budaj, Andrzej; Hijazi, Ziad; Parkhomenko, Alexander; Sinnaeve, Peter; Storey, Robert F.; Thiele, Holger ... & Alexander, John H.
  
• Defective Zn2+ homeostasis in mouse and human platelets with α-and δ-storage pool diseases. Scientific Reports, 9(1).
  Kiran, Gotru Sanjeev; van Geffen Johanna, P.; Nagy, Magdolna; Mammadova-Bach, Elmina; Eilenberger, Julia; Volz, Julia; Manukjan, Georgi; Schulze, Harald; Wagner, Leonard; Eber, Stefan; Schambeck, Christian; Deppermann, Carsten; Brouns, Sanne; Nurden, Paquita; Greinacher, Andreas; Sachs, Ulrich; Nieswandt, Bernhard; Hermanns, Heike M.; Heemskerk, Johan W. M. & Braun, Attila
  
• Imaging fibrosis in inflammatory diseases: targeting the exposed extracellular matrix. Theranostics, 9(10), 2868-2881.
  Beziere, Nicolas; Fuchs, Kerstin; Maurer, Andreas; Reischl, Gerald; Brück, Jürgen; Ghoreschi, Kamran; Fehrenbacher, Birgit; Berrio, Daniel Carvajal; Schenke-Layland, Katja; Kohlhofer, Ursula; Quintanilla-Martinez, Leticia; Gawaz, Meinrad; Kneilling, Manfred & Pichler, Bernd
  
• Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice. Blood, 133(25), 2696-2706.
  Volz, Julia; Mammadova-Bach, Elmina; Gil-Pulido, Jesus; Nandigama, Rajender; Remer, Katharina; Sorokin, Lydia; Zernecke, Alma; Abrams, Scott I.; Ergün, Süleyman; Henke, Erik & Nieswandt, Bernhard
  
• Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis. Blood, 134(21), 1847-1858.
  Geue, Sascha; Aurbach, Katja; Manke, Mailin-Christin; Manukjan, Georgi; Münzer, Patrick; Stegner, David; Brähler, Caroline; Walker-Allgaier, Britta; Märklin, Melanie; Borst, Carla E.; Quintanilla-Fend, Leticia; Rath, Dominik; Geisler, Tobias; Salih, Helmut R.; Seizer, Peter; Lang, Florian; Nieswandt, Bernhard; Gawaz, Meinrad; Schulze, Harald ... & Borst, Oliver
  
• Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer. Nature Medicine, 25(4), 641-655.
  Malehmir, Mohsen; Pfister, Dominik; Gallage, Suchira; Szydlowska, Marta; Inverso, Donato; Kotsiliti, Elena; Leone, Valentina; Peiseler, Moritz; Surewaard, Bas G. J.; Rath, Dominik; Ali, Adnan; Wolf, Monika Julia; Drescher, Hannah; Healy, Marc E.; Dauch, Daniel; Kroy, Daniela; Krenkel, Oliver; Kohlhepp, Marlene; Engleitner, Thomas ... & Heikenwalder, Mathias
  
• Platelet lamellipodium formation is not required for thrombus formation and stability. Blood, 134(25), 2318-2329.
  Schurr, Yvonne; Sperr, Andreas; Volz, Julia; Beck, Sarah; Reil, Lucy; Kusch, Charly; Eiring, Patrick; Bryson, Sheila; Sauer, Markus; Nieswandt, Bernhard; Machesky, Laura & Bender, Markus
  
• Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A. Nature Communications, 10(1).
  Körner, Andreas; Schlegel, Martin; Kaussen, Torsten; Gudernatsch, Verena; Hansmann, Georg; Schumacher, Timo; Giera, Martin & Mirakaj, Valbona
  
• A Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement. New England Journal of Medicine, 382(2), 120-129.
  Dangas, George D.; Tijssen, Jan G.P.; Wöhrle, Jochen; Søndergaard, Lars; Gilard, Martine; Möllmann, Helge; Makkar, Raj R.; Herrmann, Howard C.; Giustino, Gennaro; Baldus, Stephan; De Backer, Ole; Guimarães, Ana H.C.; Gullestad, Lars; Kini, Annapoorna; von Lewinski, Dirk; Mack, Michael; Moreno, Raúl; Schäfer, Ulrich; Seeger, Julia ... & Windecker, Stephan
  
• BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation. Journal of Clinical Investigation, 130(11), 6064-6079.
  Volz, Julia; Kusch, Charly; Beck, Sarah; Popp, Michael; Vögtle, Timo; Meub, Mara; Scheller, Inga; Heil, Hannah S.; Preu, Julia; Schuhmann, Michael K.; Hemmen, Katherina; Premsler, Thomas; Sickmann, Albert; Heinze, Katrin G.; Stegner, David; Stoll, Guido; Braun, Attila; Sauer, Markus & Nieswandt, Bernhard
  
• CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke. Circulation Research, 127(8), 1023-1035.
  Schuhmann, Michael K.; Stoll, Guido; Bieber, Michael; Vögtle, Timo; Hofmann, Sebastian; Klaus, Vanessa; Kraft, Peter; Seyhan, Mert; Kollikowski, Alexander M.; Papp, Lena; Heuschmann, Peter U.; Pham, Mirko; Nieswandt, Bernhard & Stegner, David
  
• LipidCreator workbench to probe the lipidomic landscape. Nature Communications, 11(1).
  Peng, Bing; Kopczynski, Dominik; Pratt, Brian S.; Ejsing, Christer S.; Burla, Bo; Hermansson, Martin; Benke, Peter Imre; Tan, Sock Hwee; Chan, Mark Y.; Torta, Federico; Schwudke, Dominik; Meckelmann, Sven W.; Coman, Cristina; Schmitz, Oliver J.; MacLean, Brendan; Manke, Mailin-Christin; Borst, Oliver; Wenk, Markus R.; Hoffmann, Nils & Ahrends, Robert
  
• Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived Galectin-3. Blood.
  Mammadova-Bach, Elmina; Gil-Pulido, Jesus; Sarukhanyan, Edita; Burkard, Philipp; Shityakov, Sergey; Schonhart, Charlotte; Stegner, David; Remer, Katharina; Nurden, Paquita; Nurden, Alan T.; Dandekar, Thomas; Nehez, Laszlo; Dank, Magdolna; Braun, Attila; Mezzano, Diego; Abrams, Scott I. & Nieswandt, Bernhard
  
• Platelet surface expression of cyclophilin A is associated with increased mortality in patients with symptomatic coronary artery disease. Journal of Thrombosis and Haemostasis, 18(1), 234-242.
  Rath, Dominik; von Ungern‐Sternberg, Saskia; Heinzmann, David; Sigle, Manuel; Monzien, Mona; Horstmann, Katja; Schaeffeler, Elke; Winter, Stefan; Müller, Karin; Groga‐Bada, Patrick; Zdanyte, Monika; Borst, Oliver; Zernecke, Alma; Gawaz, Meinrad; Martus, Peter; Schwab, Matthias; Geisler, Tobias & Seizer, Peter
  
• Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb. Nature Communications, 11(1).
  Köhler, David; Granja, Tiago; Volz, Julia; Koeppen, Michael; Langer, Harald F.; Hansmann, Georg; Legchenko, Ekaterina; Geisler, Tobias; Bakchoul, Tamam; Eggstein, Claudia; Häberle, Helene A.; Nieswandt, Bernhard & Rosenberger, Peter
  
• Ticagrelor causes false-negative functional tests for heparin-induced thrombocytopenia. Blood, 135(11), 875-878.
  Eekels, Julia J. M.; Pachler, Christoph; Krause, Nora; Muhr, Tina; Waltl, Gert & Greinacher, Andreas
  
• Acquired platelet GPVI receptor dysfunction in critically ill patients with sepsis. Blood, 137(22), 3105-3115.
  Weiss, Lukas J.; Manukjan, Georgi; Pflug, Annerose; Winter, Nadine; Weigel, Mathis; Nagler, Nils; Kredel, Markus; Lâm, Thiên-Trí; Nieswandt, Bernhard; Weismann, Dirk & Schulze, Harald
  
• Acute coronary syndrome is associated with a substantial change in the platelet lipidome. Cardiovascular Research, 118(8), 1904-1916.
  Harm, Tobias; Bild, Alexander; Dittrich, Kristina; Goldschmied, Andreas; Nestele, Jeremy; Chatterjee, Madhumita; Fu, Xiaoqing; Kolb, Kyra; Castor, Tatsiana; Borst, Oliver; Geisler, Tobias; Rath, Dominik; LäMmerhofer, Michael & Gawaz, Meinrad
  
• Anti–platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein. Blood, 138(14), 1269-1277.
  Greinacher, Andreas; Selleng, Kathleen; Mayerle, Julia; Palankar, Raghavendra; Wesche, Jan; Reiche, Sven; Aebischer, Andrea; Warkentin, Theodore E.; Muenchhoff, Maximilian; Hellmuth, Johannes C.; Keppler, Oliver T.; Duerschmied, Daniel; Lother, Achim; Rieg, Siegbert; Gawaz, Meinrad Paul; Mueller, Karin Anne Lydia; Scheer, Christian S.; Napp, Matthias ... & Hahnenkamp, Klaus
  
• ANXA7 Regulates Platelet Lipid Metabolism and Ca 2+ Release in Arterial Thrombosis. Circulation Research, 129(4), 494-507.
  Manke, Mailin-Christin; Geue, Sascha; Coman, Cristina; Peng, Bing; Kollotzek, Ferdinand; Münzer, Patrick; Walker, Britta; Huber, Stephan M.; Rath, Dominik; Sickmann, Albert; Stegner, David; Duerschmied, Daniel; Lang, Florian; Nieswandt, Bernhard; Gawaz, Meinrad; Ahrends, Robert & Borst, Oliver
  
• CXCL12-Abundant Reticular (CAR) Cells Direct Megakaryocyte Protrusions across the Bone Marrow Sinusoid Wall. Cells, 10(4), 722.
  Wagner, Nicole; Mott, Kristina; Upcin, Berin; Stegner, David; Schulze, Harald & Ergün, Süleyman
  
• Efficacy and Safety of Revacept, a Novel Lesion-Directed Competitive Antagonist to Platelet Glycoprotein VI, in Patients Undergoing Elective Percutaneous Coronary Intervention for Stable Ischemic Heart Disease. JAMA Cardiology, 6(7), 753.
  Mayer, Katharina; Hein-Rothweiler, Ralph; Schüpke, Stefanie; Janisch, Marion; Bernlochner, Isabell; Ndrepepa, Gjin; Sibbing, Dirk; Gori, Tommaso; Borst, Oliver; Holdenrieder, Stefan; Kupka, Danny; Petzold, Tobias; Bradaric, Christian; Okrojek, Rainer; Leistner, David M.; Trippel, Tobias D.; Münzel, Thomas; Landmesser, Ulf; Pieske, Burkert ... & Massberg, Steffen
  
• Hypothalamic dopamine neurons motivate mating through persistent cAMP signalling. Nature, 597(7875), 245-249.
  Zhang, Stephen X.; Lutas, Andrew; Yang, Shang; Diaz, Adriana; Fluhr, Hugo; Nagel, Georg; Gao, Shiqiang & Andermann, Mark L.
  
• Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia. Blood, 138(22), 2256-2268.
  Greinacher, Andreas; Selleng, Kathleen; Palankar, Raghavendra; Wesche, Jan; Handtke, Stefan; Wolff, Martina; Aurich, Konstanze; Lalk, Michael; Methling, Karen; Völker, Uwe; Hentschker, Christian; Michalik, Stephan; Steil, Leif; Reder, Alexander; Schönborn, Linda; Beer, Martin; Franzke, Kati; Büttner, Andreas; Fehse, Boris ... & Renné, Thomas
  
• Local Cerebral Recombinant Tissue Plasminogen Activator Concentrations During Acute Stroke. JAMA Neurology, 78(5), 615.
  Essig, Fabian; Kollikowski, Alexander M.; Müllges, Wolfgang; Stoll, Guido; Haeusler, Karl Georg; Schuhmann, Michael K. & Pham, Mirko
  
• LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer. Nature Cancer, 2(2), 201-217.
  Rudalska, Ramona; Harbig, Jule; Snaebjornsson, Marteinn T.; Klotz, Sabrina; Zwirner, Stefan; Taranets, Liudmyla; Heinzmann, Florian; Kronenberger, Thales; Forster, Michael; Cui, Wei; D.’Artista, Luana; Einig, Elias; Hinterleitner, Martina; Schmitz, Werner; Dylawerska, Agata; Kang, Tae-Won; Poso, Antti; Rosenfeldt, Mathias T.; Malek, Nisar P. ... & Dauch, Daniel
  
• Platelet Activation and Chemokine Release Are Related to Local Neutrophil-Dominant Inflammation During Hyperacute Human Stroke. Translational Stroke Research, 13(3), 364-369.
  Kollikowski, Alexander M.; Pham, Mirko; März, Alexander G.; Papp, Lena; Nieswandt, Bernhard; Stoll, Guido & Schuhmann, Michael K.
  
• Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer. Nature Communications, 12(1).
  Hinterleitner, Clemens; Strähle, Jasmin; Malenke, Elke; Hinterleitner, Martina; Henning, Melanie; Seehawer, Marco; Bilich, Tatjana; Heitmann, Jonas; Lutz, Martina; Mattern, Sven; Scheuermann, Sophia; Horger, Marius; Maurer, Stefanie; Walz, Juliane; Fend, Falko; Handgretinger, Rupert; Seitz, Christian; Weigelin, Bettina; Singer, Stephan ... & Zender, Lars
  
• Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice. Journal of Neuroinflammation, 18(1).
  Schuhmann, Michael K.; Bieber, Michael; Franke, Maximilian; Kollikowski, Alexander M.; Stegner, David; Heinze, Katrin G.; Nieswandt, Bernhard; Pham, Mirko & Stoll, Guido
  
• The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nature Communications, 12(1).
  Nording, Henry; Baron, Lasse; Haberthür, David; Emschermann, Frederic; Mezger, Matthias; Sauter, Manuela; Sauter, Reinhard; Patzelt, Johannes; Knoepp, Kai; Nording, Anne; Meusel, Moritz; Meyer-Saraei, Roza; Hlushchuk, Ruslan; Sedding, Daniel; Borst, Oliver; Eitel, Ingo; Karsten, Christian M.; Feil, Robert; Pichler, Bernd ... & Langer, Harald F.
  
• Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. New England Journal of Medicine, 384(22), 2092-2101.
  Greinacher, Andreas; Thiele, Thomas; Warkentin, Theodore E.; Weisser, Karin; Kyrle, Paul A. & Eichinger, Sabine
  
• Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets. Haematologica, 107(12), 2846-2858.
  Scheller, Inga; Beck, Sarah; Göb, Vanessa; Gross, Carina; Neagoe, Raluca A. I.; Aurbach, Katja; Bender, Markus; Stegner, David; Nagy, Zoltan & Nieswandt, Bernhard
  
• ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Nature Communications, 13(1).
  Rohlfing, Anne-Katrin; Kolb, Kyra; Sigle, Manuel; Ziegler, Melanie; Bild, Alexander; Münzer, Patrick; Sudmann, Jessica; Dicenta, Valerie; Harm, Tobias; Manke, Mailin-Christin; Geue, Sascha; Kremser, Marcel; Chatterjee, Madhumita; Liang, Chunguang; von, Eysmondt Hendrik; Dandekar, Thomas; Heinzmann, David; Günter, Manina; von Ungern-Sternberg, Saskia ... & Gawaz, Meinrad
  
• Foudroyant cerebral venous (sinus) thrombosis triggered through CLEC-2 and GPIIb/IIIa dependent platelet activation. Nature Cardiovascular Research, 1(2), 132-141.
  Stegner, David; Göb, Vanessa; Krenzlin, Viola; Beck, Sarah; Hemmen, Katherina; Schuhmann, Michael K.; Schörg, Barbara F.; Hackenbroch, Christian; May, Frauke; Burkard, Philipp; Pinnecker, Jürgen; Zernecke, Alma; Rosenberger, Peter; Greinacher, Andreas; Pichler, Bernd J.; Heinze, Katrin G.; Stoll, Guido & Nieswandt, Bernhard
  
• G6b-B regulates an essential step in megakaryocyte maturation. Blood Advances, 6(10), 3155-3161.
  Becker, Isabelle C.; Nagy, Zoltan; Manukjan, Georgi; Haffner-Luntzer, Melanie; Englert, Maximilian; Heib, Tobias; Vögtle, Timo; Gross, Carina; Bharti, Richa; Dietrich, Sascha; Mott, Kristina; Heck, Johannes; Stegmaier, Sebastian; Baranowsky, Anke; Schinke, Thorsten; Schlegel, Nicolas; Heckel, Tobias; Stegner, David; Pleines, Irina ... & Nieswandt, Bernhard
  
• Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes. Open Biology, 12(8).
  Zhang, Yujing; Benz, Pascal; Stehle, Daniel; Yang, Shang; Kurz, Hendrikje; Feil, Susanne; Nagel, Georg; Feil, Robert; Gao, Shiqiang & Bender, Markus
  
• Platelet ACKR3/CXCR7 favors antiplatelet lipids over anatherothrombotic lipidome and regulates thromboinflammation. Blood, 139(11), 1722-1742.
  Cebo, Malgorzata; Dittrich, Kristina; Fu, Xiaoqing; Manke, Mailin C.; Emschermann, Frederic; Rheinlaender, Johannes; von Eysmondt, Hendrik; Ferreirós, Nerea; Sudman, Jessica; Witte, Alexander; Pelzl, Lisann; Borst, Oliver; Geisler, Tobias; Rath, Dominik; Bakchoul, Tamam; Gawaz, Meinrad; Schäffer, Tilman E.; Lämmerhofer, Michael & Chatterjee, Madhumita
  
• A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury. Blood, 142(17), 1463-1477.
  Burkard, Philipp; Schonhart, Charlotte; Vögtle, Timo; Köhler, David; Tang, Linyan; Johnson, Denise; Hemmen, Katherina; Heinze, Katrin G.; Zarbock, Alexander; Hermanns, Heike M.; Rosenberger, Peter & Nieswandt, Bernhard
  
• Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation. Nature Cardiovascular Research, 2(9), 835-852.
  de Jonckheere, Bianca; Kollotzek, Ferdinand; Münzer, Patrick; Göb, Vanessa; Fischer, Melina; Mott, Kristina; Coman, Cristina; Troppmair, Nina Nicole; Manke, Mailin-Christin; Zdanyte, Monika; Harm, Tobias; Sigle, Manuel; Kopczynski, Dominik; Bileck, Andrea; Gerner, Christopher; Hoffmann, Nils; Heinzmann, David; Assinger, Alice; Gawaz, Meinrad ... & Ahrends, Robert
  
• Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo. Frontiers in Immunology, 14.
  Elgheznawy, Amro; Öftering, Patricia; Englert, Maximilian; Mott, Kristina; Kaiser, Friederike; Kusch, Charly; Gbureck, Uwe; Bösl, Michael R.; Schulze, Harald; Nieswandt, Bernhard; Vögtle, Timo & Hermanns, Heike M.
  
• Noninvasive Detection of Smooth Muscle Cell-Derived Hot Spots to Study Atherosclerosis by PET/MRI in Mice. Circulation Research, 132(6), 747-750.
  Feil, Susanne; Stowbur, Dimitri; Schörg, Barbara F.; Ehrlichmann, Walter; Reischl, Gerald; Kneilling, Manfred; Pichler, Bernd J. & Feil, Robert
  
• Platelet‐derived lipids promote insulin secretion of pancreatic β cells. EMBO Molecular Medicine, 15(9).
  Karwen, Till; Kolczynska‐Matysiak, Katarzyna; Gross, Carina; Löffler, Mona C.; Friedrich, Mike; Loza‐Valdes, Angel; Schmitz, Werner; Wit, Magdalena; Dziaczkowski, Filip; Belykh, Andrei; Trujillo‐Viera, Jonathan; El‐Merahbi, Rabih; Deppermann, Carsten; Nawaz, Sameena; Hastoy, Benoit; Demczuk, Agnieszka; Erk, Manuela; Wieckowski, Mariusz R.; Rorsman, Patrik ... & Sumara, Grzegorz