Extended fetal monitoring by systematic analysis of fetal autonomic cardiovascular regulation
Final Report Abstract
The clinically available methods for assessing the fetal health and developmental status are still too imprecise today and are often only suitable to a limited extent for prognostic applications. In early gestational age, they are partly not applicable at all. The aim of the project was to characterize the fetal state in early gestation (20-28 weeks of pregnancy) by analyzing fetal cardiovascular regulation. For this purpose, the innovative system-analytical approach was pursued to characterize the dynamics of fetal heart rate variability as a function of internal and external influencing factors, i.e. to perform a context-based fetal variability analysis. The information obtained from this should be used in the future for preventive treatment, not least for determining the optimal time of delivery in the event of complications. Within the framework of a clinical study, the project used biomedical methods of context-based variability analysis and demonstrated for the first time that (1) a characteristic longitudinal development of fetal autonomic regulation is detectable and (2) monitoring this development opens up the basis for improved care of high-risk pregnancies, which can significantly influence the decision on interventions in early gestational age.
Publications
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„The Influence of Fetal Movement to Fetal QRS Complex Morphology“, in 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Juli 2019
J. Weiß, S. Zaunseder & M. Schmidt
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Detection Quality Indices for Improved Heart Beat Assessment in Non-Invasive Fetal ECG. Computing in Cardiology Conference (CinC). Computing in Cardiology.
Weiß, Jonas; Malberg, Hagen & Schmidt, Martin
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Instantaneous Cardiac Baroreflex Sensitivity: xBRS Method Quantifies Heart Rate Blood Pressure Variability Ratio at Rest and During Slow Breathing. Frontiers in Neuroscience, 14.
Wessel, Niels; Gapelyuk, Andrej; Weiß, Jonas; Schmidt, Martin; Kraemer, Jan F.; Berg, Karsten; Malberg, Hagen; Stepan, Holger & Kurths, Jürgen
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Non-invasive foetal ECG signal quality assessment by experts and non-experts. 2020 11th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO), 1-2. IEEE.
Weiss, Jonas; Malberg, Hagen & Schmidt, Martin
