Refined multiscale and multiphysics models of electrical stimulation towards clinical applications (A02)

• Subject Area: Electronic Semiconductors, Components and Circuits, Integrated Systems, Sensor Technology, Theoretical Electrical Engineering
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 299150580

Numerical models are crucial for the patient-specific use of electrical stimulation in clinical applications. For this purpose, validated, data-driven simulations that represent bioelectrical, mechanical, and biochemical processes at various spatial and temporal scales are advanced. Imaging and sensor data individually calibrate the models to patients and clinical conditions. The applied methods combine finite and boundary element techniques with inverse modelling and model order reduction. This approach facilitates the derivation of robust, individually adapted stimulation parameters as a basis for effective therapies for brain, bone, and articular cartilage diseases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1270: ELectrically Active ImplaNts - ELAINE
• International Connection: Italy
• Applicant Institution: Universität Rostock
• Project Heads: Professor Dr.-Ing. Simon Adrian, since 1/2026; Dr.-Ing. Revathi Appali, from 7/2021 until 12/2025; Professorin Dr. Ursula van Rienen, until 12/2025; Dr. Christian Schmidt, until 6/2021; Dr.-Ing. Julius Zimmermann, since 1/2026