Electrostimulation-induced cellular responses: Biomarkers for eustress levels and model implant surfaces (A03)

• Subject Area: Cell Biology ; Biomaterials ; Experimental Condensed Matter Physics
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 299150580

The aim is to elucidate the interactions between cells (osteoblasts, stem cells) and electrical stimulation in combination with innovative material scaffolds. Detailed investigations will focus on cell physiological processes at the cell-material interface in 2D and 3D cultures, the structural and piezoelectric properties of the material surface, and their influence on cell behaviour, including calcium signalling and protein translocation, which affect cell morphology. High-resolution scanning probe microscopy methods are combined with cell biological analyses to gain a thorough understanding of these complex interactions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1270: ELectrically Active ImplaNts - ELAINE
• Applicant Institution: Universität Rostock
• Project Heads: Professorin Dr. J. Barbara Nebe, until 12/2025; Dr. Henrike Rebl, since 7/2021; Professorin Dr. Sylvia Speller