Electro-physical stimulation of osseoinduction via alloplastic osteosynthesis system after ablative surgery in the mandible (C01)

• Subject Area: Dentistry, Oral Surgery
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 299150580

Critical mandibular defects are stabilised with a specially developed, load-bearing implant system. This system features an integrated electrical stimulation unit to promote patient-specific bone regeneration. The healing process is monitored and dynamically adjusted using impedance-based feedback. The patient's stem cells are perfused directly into the bone substitute material, filling the defect and accelerating regeneration further. This strategy promotes new bone formation at the defect edges and the central defect core.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1270: ELectrically Active ImplaNts - ELAINE
• Applicant Institution: Universität Rostock
• Project Heads: Dr. Michael Dau, from 7/2021 until 9/2022; Privatdozentin Dr. Nadja Engel, since 12/2022; Professor Dr. Peer Kämmerer