Electro-physical stimulation of osseoinduction via alloplastic osteosynthesis system after ablative surgery in the mandible (C01)

• Subject Area: Dentistry, Oral Surgery
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 299150580

The project will explore electrical stimulation of bone using active osteosynthesis systems with the aim to reconstruct critical-size defects of the mandibular bone. After establishment of electrical stimulation parameters to improve growth of stem cells and preliminary animal experiments, these findings concerning electrical stimulation of osseous tissue will now be translated into coordination of conception and design of a load-bearing electrically active osteosynthesis system. In order to further improve the current implant system model, coating of the titanium surface with a dielectric ceramic with piezoelectric properties seems promising as it could be additionally used as a transducer of electrical current.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1270: ELectrically Active ImplaNts - ELAINE
• Applicant Institution: Universität Rostock
• Project Heads: Dr. Michael Dau, from 7/2021 until 9/2022; Privatdozentin Dr. Nadja Engel, since 12/2022; Professor Dr. Peer Kämmerer