Deep brain stimulation in dystonia models: Biological implementation, definition of optimal stimulation parameters, and analysis of mechanisms (C03)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 299150580

The mechanisms and therapeutic effects of deep brain stimulation in a validated animal model of dystonia are investigated. The goal is to clarify how long-term stimulation in the pallidum influences synaptic and cellular plasticity within and outside the stimulation region. Electrophysiology, high-density multi-electrode arrays, immunohistochemical analyses, and mathematical modelling are used to systematically investigate cholinergic and dopaminergic modulation, structural changes, and biomarkers. The long-term goal is to develop predictive markers and elucidate the mechanisms for future feedback-controlled deep brain stimulation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1270: ELectrically Active ImplaNts - ELAINE
• Applicant Institution: Universität Rostock
• Project Heads: Professor Dr. Rüdiger Köhling; Professorin Dr. Angelika Richter, until 12/2025; Professorin Dr. Franziska Richter Assencio, since 1/2026