Die Entschlüsselung des Poly(ADP-Ribose) Codes: Wie die strukturelle Diversität von Poly(ADP-Ribose) Molekülen zelluläre Funktionen während der genotoxischen Stressantwort beeinflusst

• Antragsteller: Professor Dr. Aswin Mangerich
• Fachliche Zuordnung: Public Health, Gesundheitsbezogene Versorgungsforschung, Sozial- und Arbeitsmedizin ; Biochemie ; Zellbiologie
• Förderung: Förderung von 2017 bis 2022
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 386775082

• Erstellungsjahr: 2023

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy. Nucleic Acids Research, 47(9), 4843-4858.
  Krüger, Annika; Stier, Anna; Fischbach, Arthur; Bürkle, Alexander; Hauser, Karin & Mangerich, Aswin
  
• PARP1 catalytic variants reveal branching and chain length-specific functions of poly(ADP-ribose) in cellular physiology and stress response. Nucleic Acids Research, 48(18), 10015-10033.
  Aberle, Lisa; Krüger, Annika; Reber, Julia M.; Lippmann, Michelle; Hufnagel, Matthias; Schmalz, Michael; Trussina, Irmela R. E. A.; Schlesiger, Sarah; Zubel, Tabea; Schütz, Karina; Marx, Andreas; Hartwig, Andrea; Ferrando-May, Elisa; Bürkle, Alexander & Mangerich, Aswin
  
• Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal. Nature Communications, 12(1).
  Rack, Johannes Gregor Matthias; Liu, Qiang; Zorzini, Valentina; Voorneveld, Jim; Ariza, Antonio; Honarmand, Ebrahimi Kourosh; Reber, Julia M.; Krassnig, Sarah C.; Ahel, Dragana; van der Marel, Gijsbert A.; Mangerich, Aswin; McCullagh, James S. O.; Filippov, Dmitri V. & Ahel, Ivan
  
• Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Molecular Cell, 81(12), 2640-2655.e8.
  Prokhorova, Evgeniia; Agnew, Thomas; Wondisford, Anne R.; Tellier, Michael; Kaminski, Nicole; Beijer, Danique; Holder, James; Groslambert, Josephine; Suskiewicz, Marcin J.; Zhu, Kang; Reber, Julia M.; Krassnig, Sarah C.; Palazzo, Luca; Murphy, Shona; Nielsen, Michael L.; Mangerich, Aswin; Ahel, Dragana; Baets, Jonathan; O.’Sullivan, Roderick J. & Ahel, Ivan
  
• Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly(ADP-ribose). Nucleic Acids Research, 49(15), 8432-8448.
  Reber, Julia M. & Mangerich, Aswin
  
• PARP1 and XRCC1 exhibit a reciprocal relationship in genotoxic stress response. Cell Biology and Toxicology, 39(1), 345-364.
  Reber, Julia M.; Božić-Petković, Jovana; Lippmann, Michelle; Mazzardo, Marvin; Dilger, Asisa; Warmers, Rebecca; Bürkle, Alexander & Mangerich, Aswin
  
• The C-Terminal Domain of Y-Box Binding Protein 1 Exhibits Structure-Specific Binding to Poly(ADP-Ribose), Which Regulates PARP1 Activity. Frontiers in Cell and Developmental Biology, 10.
  Naumenko, Konstantin N.; Sukhanova, Mariya V.; Hamon, Loic; Kurgina, Tatyana A.; Anarbaev, Rashid O.; Mangerich, Aswin; Pastré, David & Lavrik, Olga I.
  
• Influence of chain length and branching on poly(ADP-ribose)–protein interactions. Nucleic Acids Research, 51(2), 536-552.
  Löffler, Tobias; Krüger, Annika; Zirak, Peyman; Winterhalder, Martin J.; Müller, Anna-Lena; Fischbach, Arthur; Mangerich, Aswin & Zumbusch, Andreas