Photoacids and bases as responsive elements in block copolymer nanostructures for uptake and transport (A03)

• Subject Area: Preparatory and Physical Chemistry of Polymers
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

The project addresses triggered drug release by red / NIR light from new polymeric nanocontainers. To this end we research different block copolymer concepts to couple triplet-triplet annihilation upconversion to chemical reactivity of photoacids and photobases leading to drug release. Furthermore, based on polymers developed during the first funding period we will study the light-mediated formation and dissociation of interpolyelectrolyte complexes (IPECs) as another tool for drug transport and temporally controlled release.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Benjamin Dietzek-Ivansic; Professor Dr. Klaus D. Jandt, until 6/2021; Professor Dr. Felix H. Schacher