Molecular characterization of Myoscape, a novel L-type Calcium channel binding protein involved in cardiac Calcium cycling, contractility and pathological hypertrophy

• Applicant: Dr. Matthias Eden
• Subject Area: Cardiology, Angiology
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 387388507

• Final Report Year: 2022

No abstract available

Publications

• Myoscape and BIN1 - Two new direct interaction-partners in the pathomechanism of calcineurin-induced cardiac hypertrophy in vitro and in vivo“ prämierter Vortrag auf der 83. Jahrestagung der Deutschen Gesellschaft für Kardiologie 2017
  Matthias Eden
  
• „ Myoscape/STRIP2 is a novel player in LTCC membrane trafficking and cardiac EC Coupling “. Retreat Deutsches Zentrum für Herzkreislaufforschung (DZHK) 2019 MST 4, a novel STRIPAK associated Kinase is upregulated in human cardiomyopathy and regulates cardiomyocyte hypertrophy, contractility and apoptosis, Annual world congress American Heart Association 2020
  Matthias Eden
  
• A novel "loss of function" Myoscape mutation derived from patients with Dilated Cardiomyopathy and Short-QT syndrome affects cardiac output in zebrafish in vivo and hypertrophic gene program in vitro Clin Res Cardiol
  B. Völschow, A. Farahvashi, M. Leye, C. Tannert, P. Doldi, N. Frey & M. Eden