Immunomodulatory injectable microporous hydrogel scaffolds for the promotion of dermal healing in chronic wounds
Biomaterials
Final Report Abstract
The research project did highlight the potential of microgel based scaffolds for the use in wound healing applications. Through their unique geometry they allow for fast cell infiltration, while at the same time supporting the tissue and wound stability through enzymatic crosslinking with the adjacent wound surface. As a platform technology we could show, that the microgels are well suited to release multiple signaling mediators to suppress inflammation or promote healing. Works by Mealy et al. showed how heterogenous, mixed particles can be used to enable timedependent, responsive biofunctionality, e.g. through release of a signaling mediator from proteolytically cleavable microgels. Therefore, we are planning continue the project on the IL-4/IL-10 functionalized MAP scaffolds and extend the work on MAP-based wound healing applications.
Publications
- (2019). Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration. Current Opinion in Biotechnology, 60, 1–8
Riley, L., Schirmer, L., & Segura, T.
(See online at https://doi.org/10.1016/j.copbio.2018.11.001)
