Bioinspired guanidinium-containing nanoparticles for gene delivery (B03)

• Subject Area: Pharmacy
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

Project B03 will focus on the synthesis of safe and efficient gene carriers like guanidinium containing terpolymers with a systematic control of the hydrophilic-hydrophobic balance. The terpolymers will be formulated with nucleic acids where the resulting polyplexes will be applied as anti-inflammatory treatment based on NF-kB knockdown. The materials will be tested in cell culture systems like endothelial cells or epithelial intestinal models and M1 / M2 macrophages.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professorin Dr. Dagmar Fischer; Professorin Kalina Peneva, Ph.D.