Biophotonic characterisation of the interaction of nanoparticles and drugs with hepatic stellate cells (C01)

• Subject Area: Preparatory and Physical Chemistry of Polymers
• Term: since 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 316213987

Dextran derivatives and polyesters are synthesised and used as carrier materials for inhibitors that target inflammatory pathways in hepatic stellate cells to slow down the development of liver fibrosis. Advanced biophotonic imaging is utilised to characterise the inhibitor-loaded nanoparticles in cells or directly in the liver. The nanoparticle induced modulation and activation of stellate cells are also analysed through omics-methods. These joint efforts allow for novel approaches to therapeutically target hepatic stellate cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1278: Polymer-based nanoparticle libraries for targeted anti-inflammatory strategies
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Michael Bauer; Professor Dr. Jürgen Popp; Dr. Stephanie Schubert