Dendritic computations underlying formation of feature-selectivity in CA1 and their impairment in mouse models of Alzheimer’s disease (C07*)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology
• Term: from 2017 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 227953431

This project proposes to combine dendritic calcium imaging in behaving animals and mathematical techniques to study dendritic computations underlying the formation of spatial selectivity in CA1 pyramidal cells, and to determine how they are impaired in mouse models of Alzheimer’s disease.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1089: Synaptic Micronetworks in Health and Disease
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Jakob Macke; Professor Dr. Stefan Remy