Molekulare Pathogenese des nodulären lymphozytenprädominanten Hodgkin Lymphoms und verwandter Neoplasien

• Antragstellerin: Professorin Dr. Sylvia Hartmann
• Fachliche Zuordnung: Pathologie
• Förderung: Förderung von 2017 bis 2024
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 390340829

• Erstellungsjahr: 2022

Zusammenfassung der Projektergebnisse

In summary, we provide in this project several new data that elucidate the development, progression and transformation of NLPHL. We could for the first time pin down a specific protein of an infectious agens as trigger of a malignant lymphoma. Our understanding of NLPHL biology and pathology has significantly increased, which will also translate in an ameliorated management of NLPHL patients.

Projektbezogene Publikationen (Auswahl)

• JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma. Haematologica, 104(2), 330-337.
  Schuhmacher, Bianca; Bein, Julia; Rausch, Tobias; Benes, Vladimir; Tousseyn, Thomas; Vornanen, Martine; Ponzoni, Maurilio; Thurner, Lorenz; Gascoyne, Randy; Steidl, Christian; Küppers, Ralf; Hansmann, Martin-Leo & Hartmann, Sylvia
  
• The time to relapse correlates with the histopathological growth pattern in nodular lymphocyte predominant Hodgkin lymphoma. American Journal of Hematology, 94(11), 1208-1213.
  Hartmann, Sylvia; Plütschow, Annette; Mottok, Anja; Bernd, Heinz‐Wolfram; Feller, Alfred C.; Ott, German; Cogliatti, Sergio; Fend, Falko; Quintanilla‐Martinez, Leticia; Stein, Harald; Klapper, Wolfram; Möller, Peter; Rosenwald, Andreas; Engert, Andreas; Hansmann, Martin‐Leo & Eichenauer, Dennis A.
  
• Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma. Nature Communications, 11(1).
  Thurner, Lorenz; Hartmann, Sylvia; Fadle, Natalie; Regitz, Evi; Kemele, Maria; Kim, Yoo-Jin; Bohle, Rainer Maria; Nimmesgern, Anna; von Müller, Lutz; Kempf, Volkhard A. J.; Weniger, Marc A.; Neumann, Frank; Schneider, Nadine; Vornanen, Martine; Sundström, Christer; de Leval, Laurence; Engert, Andreas; Eichenauer, Dennis A.; Küppers, Ralf ... & Pfreundschuh, Michael
  
• Lymphocyte predominant cells of nodular lymphocyte predominant Hodgkin lymphoma interact with rosetting T cells in an immunological synapse. American Journal of Hematology, 95(12), 1495-1502.
  Bein, Julia; Thurner, Lorenz; Hansmann, Martin‐Leo & Hartmann, Sylvia
  
• Deregulated miRNAs Contribute to Silencing of B-Cell Specific Transcription Factors and Activation of NF-κB in Classical Hodgkin Lymphoma. Cancers, 13(13), 3131.
  Paczkowska, Julia; Janiszewska, Joanna; Ustaszewski, Adam; Bein, Julia; Skalski, Marcin; Dzikiewicz-Krawczyk, Agnieszka; Rozwadowska, Natalia; Hansmann, Martin-Leo; Hartmann, Sylvia & Giefing, Maciej
  
• Evolutionary clonal trajectories in nodular lymphocyte-predominant Hodgkin lymphoma with high risk of transformation. Haematologica, 106(10), 2654-2666.
  Paschold, Lisa; Willscher, Edith; Bein, Julia; Vornanen, Martine; Eichenauer, Dennis A.; Simnica, Donjete; Thiele, Benjamin; Wickenhauser, Claudia; Rosenwald, Andreas; Bernd, Heinz-Wolfram; Klapper, Wolfram; Feller, Alfred C.; Ott, German; Fend, Falko; Hartmann, Sylvia & Binder, Mascha
  
• Histopathological growth patterns in patients with advanced nodular lymphocyte‐predominant Hodgkin lymphoma treated within the randomized HD18 study: a report from the German Hodgkin Study Group. British Journal of Haematology, 196(1), 99-104.
  Eichenauer, Dennis A.; Bühnen, Ina; Kreissl, Stefanie; Goergen, Helen; Fuchs, Michael; von Tresckow, Bastian; Rosenwald, Andreas; Klapper, Wolfram; Hansmann, Martin‐Leo; Möller, Peter; Bernd, Heinz‐Wolfram; Feller, Alfred C.; Engert, Andreas; Borchmann, Peter & Hartmann, Sylvia
  
• Landscape of 4D Cell Interaction in Hodgkin and Non-Hodgkin Lymphomas. Cancers, 13(20), 5208.
  Hartmann, Sylvia; Scharf, Sonja; Steiner, Yvonne; Loth, Andreas G.; Donnadieu, Emmanuel; Flinner, Nadine; Poeschel, Viola; Angel, Stephanie; Bewarder, Moritz; Bein, Julia; Brunnberg, Uta; Bozzato, Alessandro; Schick, Bernhard; Stilgenbauer, Stephan; Bohle, Rainer M.; Thurner, Lorenz & Hansmann, Martin-Leo
  
• 3D analyses reveal T cells with activated nuclear features in T-cell/histiocyte-rich large B-cell lymphoma. Modern Pathology, 35(10), 1431-1438.
  Sadeghi, Shoreh Deli Aresu; Scharf, Sonja; Steiner, Yvonne; Bein, Julia; Hansmann, Martin-Leo & Hartmann, Sylvia
  
• Tumour cell characteristics and microenvironment composition correspond to clinical presentation in newly diagnosed nodular lymphocyte‐predominant Hodgkin lymphoma. British Journal of Haematology, 199(3), 382-391.
  Hartmann, Sylvia; Soltani, Ahmad Sajad; Bankov, Katrin; Bein, Julia; Hansmann, Martin‐Leo; Rosenwald, Andreas; Bernd, Heinz‐Wolfram; Feller, Alfred; Ott, German; Möller, Peter; Stein, Harald; Klapper, Wolfram; Borchmann, Peter; Engert, Andreas & Eichenauer, Dennis A.