GSC 214: Graduiertenschule für Mikrobielle Kommunikation - Jena
Zusammenfassung der Projektergebnisse
Ziel der 2006 gegründeten „Jena School for Microbial Communication“ (JSMC) ist es, die Kommunikationsprozesse von Mikroorganismen mit anderen Mikroorganismen, mit Pflanzen, Tieren und dem Menschen und von Mikroorganismen mit der abiotischen Umwelt aufzuklären. Dieses Forschungskonzept bildet die Basis für die Ausbildung junger Wissenschaftler und bindet auch außeruniversitäre Forschungseinrichtungen und Industriepartner in gemeinschaftlich betreuten Forschungsprojekten ein. In elf thematisch auf die JSMC ausgerichteten Master-Studiengängen an der Friedrich Schiller Universität Jena werden hoch motivierte junge Wissenschaftler für das strukturierte, fächerübergreifende und forschungsorientierte Programm qualifiziert, die mit internationalen Bewerbern um die Aufnahme in die JSMC konkurrieren. Die Kommunikation von Mikroorganismen basiert auf dem Informationsfluss zwischen Organismen derselben Art, verschiedenen Arten und auf Interaktionen mit höheren Organismen und der Umwelt. Mediatoren der Kommunikation sind häufig kleine Moleküle, die von einem der Partner produziert und vom anderen in Regulationsprozesse übersetzt werden. Das detaillierte Verständnis von chemischen Signalen, ihrer räumlichen Ausbreitung, Wahrnehmung und Entzifferung mit allen nachgeordneten Entwicklungsprozessen ist nur durch die Integration der Disziplinen Biologie, Chemie, Medizin, Geologie, Optik / Physik und Systembiologie möglich. Aus den erhaltenen Ergebnissen wird langfristig die Modellierung homo- und heterogener Konsortien in der Umwelt oder in Assoziation mit einem Wirt resultieren. Während ihrer bisherigen Laufzeit hat die JSMC zur Ausbildung hoch qualifizierter Wissenschaftler zu einem hohen wissenschaftlichen Ertrag und zur internationalen Sichtbarkeit Jenas geführt. Das bemerkenswerte Engagement der Doktoranden bei der Organisation von Konferenzen oder der Weiterentwicklung des Ausbildungsprogramms resultiert aus der Rekrutierung von hoch qualifizierten jungen Wissenschaftlern. Mit einer Quote von über 40% ihrer Doktoranden aus dem Ausland hat die JSMC maßgeblich zur Internationalisierung der Forschung in Jena beigetragen und sich zudem als Vorreiter bei der Entwicklung einer Doktorandenkultur and der Friedrich Schiller Universität (FSU) erwiesen. Das academische Netzwerk der JSMC war weiterhin ein wichtiger Ausgangspunkt zur Erwerbung von etlichen Sonderforschungsbereichen und einem Excellenz Cluster. Mit der Beendung der Förderung fűr Graduiertenschulen in der DFG Exzellenz Strategie, die sich auf Forschungscluster zuspitzt, ist es der JSMC gelungen, Förderung von der Carl Zeiss Stiftung bis Ende 2024 einzugewinnen, mit der Möglichkeit diese danach zu verlängern. Die Unterstűtzung der Zeiss Stiftung basiert auf dem Ziel, die Stärken der JSMC mit denen der Abbe School for Photonics (ASP) zu kombinieren als Allianz der Jenaer Graduiertenschulen “Life in Focus”. Zielsetzungen dieser Zusammenarbeit ist die Weiterentwicklung der Promotionen in den Bereichen Mentoring und Training, und diese sollen auf Wissenschaftler nach der Promotion, also in der PostDoc Phase, ausgeweitet werden. Gleichzeitig werden wir sowohl die Industriekooperationen als auch die internationalen Internships für Doktoranden und Postdocs weiter entwickeln. Insgesamt werden das Forschungs- und Trainingsprogramm weiterhin die Möglichkeit zur Ausbildung kompetitiver und erfolgreicher Wissenschaftler für Grundlagen- und angewandte Forschung bieten.
Projektbezogene Publikationen (Auswahl)
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(2008) Non-uniform distribution of glucosinolates in Arabidopsis thaliana leaves has important consequences for plant defense. Proc Natl Acad Sci USA 105: 6196
Shroff, Rohit; Vergara, Fredd; Muck, Alexander; Svatoš, Aleš & Gershenzon, Jonathan
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(2009) Acid-base-driven matrix-assisted mass spectrometry for targeted metabolomics. Proc Natl Acad Sci USA 106: 10092
Shroff, Rohit; Rulíšek, Lubomír; Doubský, Jan & Svatoš, Aleš
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(2009) Divergent investment strategies of Acacia myrmecophytes and the coexistence of mutualists and exploiters. Proc Natl Acad Sci USA 106: 18091
Heil, Martin; González-Teuber, Marcia; Clement, Lars W.; Kautz, Stefanie; Verhaagh, Manfred & Bueno, Juan Carlos Silva
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(2009) Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation. Blood 114: 2439
Heinen, Stefan; Hartmann, Andrea; Lauer, Nadine; Wiehl, Ulrike; Dahse, Hans-Martin; Schirmer, Sylvia; Gropp, Katharina; Enghardt, Tina; Wallich, Reinhard; Hälbich, Steffi; Mihlan, Michael; Schlötzer-Schrehardt, Ursula; Zipfel, Peter F. & Skerka, Christine
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(2009) Hidden biosynthetic treasures brought to light. Nat Chem Biol 5: 450
Hertweck, Christian
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(2009) Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci USA 106: 14558
Schroeckh, Volker; Scherlach, Kirstin; Nützmann, Hans-Wilhelm; Shelest, Ekaterina; Schmidt-Heck, Wolfgang; Schuemann, Julia; Martin, Karin; Hertweck, Christian & Brakhage, Axel A.
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(2009) Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 460: 1117
Aimanianda, Vishukumar; Bayry, Jagadeesh; Bozza, Silvia; Kniemeyer, Olaf; Perruccio, Katia; Elluru, Sri Ramulu; Clavaud, Cécile; Paris, Sophie; Brakhage, Axel A.; Kaveri, Srini V.; Romani, Luigina & Latgé, Jean-Paul
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(2010) Genome sequence of the model mushroom Schizophyllum commune. Nature Biotechnology 28: 957
Ohm, Robin A.; De Jong, Jan F.; Lugones, Luis G.; Aerts, Andrea; Kothe, Erika; Stajich, Jason E.; De Vries, Ronald P.; Record, Eric; Levasseur, Anthony; Baker, Scott E.; Bartholomew, Kirk A.; Coutinho, Pedro M.; Erdmann, Susann; Fowler, Thomas J.; Gathman
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(2010) Reductive dehalogenation of brominated ethenes by Sulfurospirillum multivorans and Desulfitobacterium hafniense PCE-S. Environ Microbiol 12: 501
Ye, Lidan; Schilhabel, Anke; Bartram, Stefan; Boland, Wilhelm & Diekert, Gabriele
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(2010) Regulation of extrafloral nectar secretion by jasmonates in lima bean is light dependent. Proc Natl Acad Sci USA 107: 17228
Radhika, Venkatesan; Kost, Christian; Mithöfer, Axel & Boland, Wilhelm
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(2011) Bacteria induced natural product formation in the fungus Aspergillus nidulans requires Saga / Ada mediated histone acetylation. Proc Natl Acad Sci USA 108: 14282
Nützmann, Hans-Wilhelm; Reyes-Dominguez, Yazmid; Scherlach, Kirstin; Schroeckh, Volker; Horn, Fabian; Gacek, Agnieszka; Schümann, Julia; Hertweck, Christian; Strauss, Joseph & Brakhage, Axel A.
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(2011) Beta-2 glycoprotein 1 (beta-2GPI), the major target in anti phospholipid syndrome (APS), is a special human complement regulator. Blood 118: 2774
Gropp, Katharina; Weber, Nadia; Reuter, Michael; Micklisch, Sven; Kopka, Isabell; Hallström, Teresia & Skerka, Christine
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(2011) Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. Angew Chem Int Ed Engl 50 : 9843
Scherlach, Kirstin; Nützmann, Hans‐Wilhelm; Schroeckh, Volker; Dahse, Hans‐Martin; Brakhage, Axel A. & Hertweck, Christian
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(2011) Plasmonic nanofabrication by long-range excitation transfer via DNA nanowire. Nano Lett 11: 1505
Wirth, J.; Garwe, F.; Hähnel, G.; Csáki, A.; Jahr, N.; Stranik, O.; Paa, W. & Fritzsche, W.
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(2012) Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium. Angew Chem Int Ed Engl 51: 2425
Behnken, Swantje; Lincke, Thorger; Kloss, Florian; Ishida, Keishi & Hertweck, Christian
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(2012) Far-field imaging for direct visualization of light interference in GaAs nanowires. Nano Lett 12: 5412
Grange, Rachel; Brönstrup, Gerald; Kiometzis, Michael; Sergeyev, Anton; Richter, Jessica; Leiterer, Christian; Fritzsche, Wolfgang; Gutsche, Christoph; Lysov, Andrey; Prost, Werner; Tegude, Franz-Josef; Pertsch, Thomas; Tünnermann, Andreas & Christiansen, Silke
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(2012) Imaging mass spectrometry and genome mining reveal highly antifungal virulence factor of mushroom soft rot pathogen. Angew Chem Int Ed Engl 51: 13173
Graupner, Katharina; Scherlach, Kirstin; Bretschneider, Tom; Lackner, Gerald; Roth, Martin; Gross, Harald & Hertweck, Christian
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(2012) Liver dysfunction and phosphatidylinositol- 3- kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLOS Medicine 9: e1001338
Recknagel, Peter; Gonnert, Falk A.; Westermann, Martin; Lambeck, Sandro; Lupp, Amelie; Rudiger, Alain; Dyson, Alex; Carré, Jane E.; Kortgen, Andreas; Krafft, Christoph; Popp, Jürgen; Sponholz, Christoph; Fuhrmann, Valentin; Hilger, Ingrid; Claus, Ralf A.; Riedemann, Niels C.; Wetzker, Reinhard; Singer, Mervyn; Trauner, Michael; ... & Bauer, Michael
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(2013) Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavus. Angew Chem Int Ed Engl 52: 1590
Forseth, Ry R.; Amaike, Saori; Schwenk, Daniel; Affeldt, Katharyn J.; Hoffmeister, Dirk; Schroeder, Frank C. & Keller, Nancy P.
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(2013) Metabolomics enables the structure elucidation of a Diatom sex pheromone. Angewandte Chemie 52: 854
Gillard, Jeroen; Frenkel, Johannes; Devos, Valerie; Sabbe, Koen; Paul, Carsten; Rempt, Martin; Inzé, Dirk; Pohnert, Georg; Vuylsteke, Marnik & Vyverman, Wim
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he Heliconius Genome Consortium (2012) Butterfly genome reveals promiscuous exchange of mimicry adaptations among species. Nature 487: 94
Dasmahapatra K K, ... Jiggins C D
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(2013) Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Cell Host Microbe 13: 29
Simon, Nina; Lasonder, Edwin; Scheuermayer, Matthias; Kuehn, Andrea; Tews, Sabrina; Fischer, Rainer; Zipfel, Peter F.; Skerka, Christine & Pradel, Gabriele
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(2013) Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway. Proc Natl Acad Sci USA 110: 4194
Frick, Sindy; Nagel, Raimund; Schmidt, Axel; Bodemann, René R.; Rahfeld, Peter; Pauls, Gerhard; Brandt, Wolfgang; Gershenzon, Jonathan; Boland, Wilhelm & Burse, Antje
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(2013) Multifactorial control of iteration events in a modular polyketide assembly line. Angew Chem Int Ed Engl 52: 5285
Busch, Benjamin; Ueberschaar, Nico; Behnken, Swantje; Sugimoto, Yuki; Werneburg, Martina; Traitcheva, Nelly; He, Jing & Hertweck, Christian
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(2013) Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 369: 111
Lo-Coco, Francesco; Avvisati, Giuseppe; Vignetti, Marco; Thiede, Christian; Orlando, Sonia Maria; Iacobelli, Simona; Ferrara, Felicetto; Fazi, Paola; Cicconi, Laura; Di Bona, Eros; Specchia, Giorgina; Sica, Simona; Divona, Mariadomenica; Levis, Alessandro; Fiedler, Walter; Cerqui, Elisa; Breccia, Massimo; Fioritoni, Giuseppe; Salih, Helmut R.; ... & Platzbecker, Uwe
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(2013) Small molecules intercept Notch signalling and the early secretory pathway. Nat Chem Biol 9: 731
Krämer, Andreas; Mentrup, Torben; Kleizen, Bertrand; Rivera-Milla, Eric; Reichenbach, Daniela; Enzensperger, Christoph; Nohl, Richard; Täuscher, Eric; Görls, Helmar; Ploubidou, Aspasia; Englert, Christoph; Werz, Oliver; Arndt, Hans-Dieter & Kaether, Christoph
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(2014) Complement factor H-related hybrid protein deregulates complement in dense deposit disease. J Clin Invest 124: 144
Chen, Qian; Wiesener, Michael; Eberhardt, Hannes U.; Hartmann, Andrea; Uzonyi, Barbara; Kirschfink, Michael; Amann, Kerstin; Buettner, Maike; Goodship, Tim; Hugo, Christian; Skerka, Christine & Zipfel, Peter F.
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(2014) Biosynthesis of the halogenated mycotoxin aspirochlorine in koji mold involves a cryptic amino acid conversion. Angew Chem Int Ed Engl 53: 13409
Chankhamjon, Pranatchareeya; Boettger‐Schmidt, Daniela; Scherlach, Kirstin; Urbansky, Barbara; Lackner, Gerald; Kalb, Daniel; Dahse, Hans‐Martin; Hoffmeister, Dirk & Hertweck, Christian
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(2014) Cell type-specific delivery of short interfering RNAs by dyefunctionalised theranostic nanoparticles. Nature Communications 5: 5565
Press, Adrian T.; Traeger, Anja; Pietsch, Christian; Mosig, Alexander; Wagner, Michael; Clemens, Mark G.; Jbeily, Nayla; Koch, Nicole; Gottschaldt, Michael; Bézière, Nicolas; Ermolayev, Volodymyr; Ntziachristos, Vasilis; Popp, Jürgen; Kessels, Michael M.; Qualmann, Britta; Schubert, Ulrich S. & Bauer, Michael
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(2014) Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles. Angew Chem Int Ed Engl 53: 11645
Heine, Daniel; Bretschneider, Tom; Sundaram, Srividhya & Hertweck, Christian
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(2014) Plasmonicallyenhanced electron escape from gold nanoparticles and their polarization-dependent excitation transfer along DNA nanowires. Nano Letters 14: 3809
Wirth, J.; Garwe, F.; Meyer, R.; Csáki, A.; Stranik, O. & Fritzsche, W.
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(2014) Polarization-resolved near-field mapping of plasmonic aperture emission by a dual-SNOM system. Nano Lett 14: 5010
Klein, Angela E.; Janunts, Norik; Steinert, Michael; Tünnermann, Andreas & Pertsch, Thomas
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(2014) Resolving a misconception about structured illumination. Nature Photonics 8: 342
Wicker, Kai & Heintzmann, Rainer
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(2014) Structural basis for organohalide respiration. Science 346: 455
Bommer, Martin; Kunze, Cindy; Fesseler, Jochen; Schubert, Torsten; Diekert, Gabriele & Dobbek, Holger
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(2014). Arabidopsis SEPALLATA proteins differ in cooperative DNA-binding during the formation of floral quartet-like complexes. Nucl Acids Res 42: 10927
Jetha, Khushboo; Theißen, Günter & Melzer, Rainer
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(2015) Tracking heavy water (D2O) incorporation for identifying and sorting active mircobial cells. PNAS 112: E194
Berry, David; Mader, Esther; Lee, Tae Kwon; Woebken, Dagmar; Wang, Yun; Zhu, Di; Palatinszky, Marton; Schintlmeister, Arno; Schmid, Markus C.; Hanson, Buck T.; Shterzer, Naama; Mizrahi, Itzhak; Rauch, Isabella; Decker, Thomas; Bocklitz, Thomas; Popp, Jürgen; Gibson, Christopher M.; Fowler, Patrick W.; Huang, Wei E.; ... & Wagner, Michael
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(2016) Tuning of Spectral and Angular Distribution of Scattering from Single Gold Nanoparticles by Subwavelength Interference Layers. Nano Letters 14: 570
Wirth, J.; Garwe, F.; Bergmann, J.; Paa, W.; Csaki, A.; Stranik, O. & Fritzsche, W.
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(2015) Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes. Nat Methods 12: 445
Hasenberg, Anja; Hasenberg, Mike; Männ, Linda; Neumann, Franziska; Borkenstein, Lars; Stecher, Manuel; Kraus, Andreas; Engel, Daniel R; Klingberg, Anika; Seddigh, Pegah; Abdullah, Zeinab; Klebow, Sabrina; Engelmann, Swen; Reinhold, Annegret; Brandau, Sven; Seeling, Michaela; Waisman, Ari; Schraven, Burkhart; Göthert, Joachim R; ... & Gunzer, Matthias
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(2015) Defining the transcriptomic landscape of Candida glabrata by RNA- Seq. Nucleic Acids Res 43: 1392
Linde, Jörg; Duggan, Seána; Weber, Michael; Horn, Fabian; Sieber, Patricia; Hellwig, Daniela; Riege, Konstantin; Marz, Manja; Martin, Ronny; Guthke, Reinhard & Kurzai, Oliver
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(2015) Detection of vancomycin in neterococci within 3 ½ hours. Sci Rep 5: 8217
-Ch. Schröder, U.; Beleites, C.; Assmann, C.; Glaser, U.; Hübner, U.; Pfister, W.; Fritzsche, W.; Popp, J. & Neugebauer, U.
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(2015) Metabolic cross-feeding via intercellular nanotubes among bacteria. Nat Comm 6: 6238
Pande, Samay; Shitut, Shraddha; Freund, Lisa; Westermann, Martin; Bertels, Felix; Colesie, Claudia; Bischofs, Ilka B. & Kost, Christian
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(2015) Native rootassociated bacteria rescue a plant from a sudden-wilt disease that emerged during continuous cropping. PNAS 112: E5013
Santhanam, Rakesh; Luu, Van Thi; Weinhold, Arne; Goldberg, Jay; Oh, Youngjoo & Baldwin, Ian T.
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(2015) Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching. Nat Chem Biol 11: 949
Sundaram, Srividhya; Heine, Daniel & Hertweck, Christian
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(2015) Pyridine-type alkaloid composition affects bacterial community composition of floral nectar. Scientific Reports 5: 11536
Aizenberg-Gershtein, Yana; Izhaki, Ido; Santhanam, Rakesh; Kumar, Pavan; Baldwin, Ian T. & Halpern, Malka
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(2016) Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nat Chem Biol 12: 6
Kries, Hajo; Caputi, Lorenzo; Stevenson, Clare E. M.; Kamileen, Mohammed O.; Sherden, Nathaniel H.; Geu-Flores, Fernando; Lawson, David M. & O'connor, Sarah E.
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(2016) A blue-light photoreceptor mediates the feedback regulation of photosynthesis. Nature 537: 563
Petroutsos, Dimitris; Tokutsu, Ryutaro; Maruyama, Shinichiro; Flori, Serena; Greiner, Andre; Magneschi, Leonardo; Cusant, Loic; Kottke, Tilman; Mittag, Maria; Hegemann, Peter; Finazzi, Giovanni & Minagawa, Jun
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(2016) A sex-inducing pheromone triggers cell cycle arrest and mate attraction in the diatom Seminavis robusta. Sci Rep 6: 19252
Moeys, Sara; Frenkel, Johannes; Lembke, Christine; Gillard, Jeroen T. F.; Devos, Valerie; Van den Berge, Koen; Bouillon, Barbara; Huysman, Marie J. J.; De Decker, Sam; Scharf, Julia; Bones, Atle; Brembu, Tore; Winge, Per; Sabbe, Koen; Vuylsteke, Marnik; Clement, Lieven; De Veylder, Lieven; Pohnert, Georg & Vyverman, Wim
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(2016) Altered carbon turnover processes and microbiomes in soils under long-term extrely high CO2 exposure. Nat Microbiol 1: 15025
Beulig, Felix; Urich, Tim; Nowak, Martin; Trumbore, Susan E.; Gleixner, Gerd; Gilfillan, Gregor D.; Fjelland, Kristine E. & Küsel, Kirsten
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(2016) Bacterial alkaloids prevent amoebal predation. Angew Chem Int Ed Engl 55: 8944
Klapper, Martin; Götze, Sebastian; Barnett, Robert; Willing, Karsten & Stallforth, Pierre
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(2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532: 64
Moyes, David L.; Wilson, Duncan; Richardson, Jonathan P.; Mogavero, Selene; Tang, Shirley X.; Wernecke, Julia; Höfs, Sarah; Gratacap, Remi L.; Robbins, Jon; Runglall, Manohursingh; Murciano, Celia; Blagojevic, Mariana; Thavaraj, Selvam; Förster, Toni M.; Hebecker, Betty; Kasper, Lydia; Vizcay, Gema; Iancu, Simona I.; Kichik, Nessim; ... & Naglik, Julian R.
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(2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. Sci Rep 6: 27807
Pollmächer, Johannes; Timme, Sandra; Schuster, Stefan; Brakhage, Axel A.; Zipfel, Peter F. & Figge, Marc Thilo
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(2016) Dual species transcriptional profling during system candidiasis reveals organ-speficic host-pathogen interactions. Sci Rep 6: 39423
Hebecker, Betty; Vlaic, Sebastian; Conrad, Theresia; Bauer, Michael; Brunke, Sascha; Kapitan, Mario; Linde, Jörg; Hube, Bernhard & Jacobsen, Ilse D.
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(2016) Immune modulation enables a specialist insect to benefit from antibacterial withanolides in its host plant. Nat comm 7:12530
Barthel, Andrea; Vogel, Heiko; Pauchet, Yannick; Pauls, Gerhard; Kunert, Grit; Groot, Astrid T.; Boland, Wilhelm; Heckel, David G. & Heidel-Fischer, Hanna M.
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(2016) Plant-like biosynthesis of isoquiline alkaloids in Aspergillus fumigatus. Nat Chem Biol 12: 419
Baccile, Joshua A.; Spraker, Joseph E.; Le, Henry H.; Brandenburger, Eileen; Gomez, Christian; Bok, Jin Woo; Macheleidt, Juliane; Brakhage, Axel A.; Hoffmeister, Dirk; Keller, Nancy P. & Schroeder, Frank C.
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(2016) Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice. PNAS 113: E1306
Li, Jun; Sung, Cecilia Ying Ju; Lee, Nikki; Ni, Yueqiong; Pihlajamäki, Jussi; Panagiotou, Gianni & El-Nezami, Hani
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(2016) Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell 167: 1067
Bacher, Petra; Heinrich, Frederik; Stervbo, Ulrik; Nienen, Mikalai; Vahldieck, Marco; Iwert, Christina; Vogt, Katrin; Kollet, Jutta; Babel, Nina; Sawitzki, Birgit; Schwarz, Carsten; Bereswill, Stefan; Heimesaat, Markus M.; Heine, Guido; Gadermaier, Gabriele; Asam, Claudia; Assenmacher, Mario; Kniemeyer, Olaf; Brakhage, Axel A.; ... & Scheffold, Alexander
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(2016) Selective silicatedirected motility in diatoms. Nat Comm 7: 10540
Bondoc, Karen Grace V.; Heuschele, Jan; Gillard, Jeroen; Vyverman, Wim & Pohnert, Georg
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(2016) Single cell analysis in native tissue: Quantification of the retinoid content of hepatic stellate cells. Sci Rep 6: 24155
Galler, Kerstin; Requardt, Robert Pascal; Glaser, Uwe; Markwart, Robby; Bocklitz, Thomas; Bauer, Michael; Popp, Jürgen & Neugebauer, Ute
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(2016) Standardizing the resolution claims for coherent microscopy. Nature Photonics 9: 68
Horstmeyer, Roarke; Heintzmann, Rainer; Popescu, Gabriel; Waller, Laura & Yang, Changhuei
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(2016) The crystal structure of Peroxiredoxin Asp f3 profides mechanistic insight into oxidative stress resistance and virulence of Aspergillus fumigatus. Sci Rep 6: 33396
Hillmann, Falk; Bagramyan, Karine; Straßburger, Maria; Heinekamp, Thorsten; Hong, Teresa B.; Bzymek, Krzysztof P.; Williams, John C.; Brakhage, Axel A. & Kalkum, Markus
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(2017) Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina. EMBO Mol Med 9: 154
Karlstetter, Marcus; Kopatz, Jens; Aslanidis, Alexander; Shahraz, Anahita; Caramoy, Albert; Linnartz‐Gerlach, Bettina; Lin, Yuchen; Lückoff, Anika; Fauser, Sascha; Düker, Katharina; Claude, Janine; Wang, Yiner; Ackermann, Johannes; Schmidt, Tobias; Hornung, Veit; Skerka, Christine; Langmann, Thomas & Neumann, Harald
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(2017) A new solution concept for the ultimatum game leading to the Golden Ratio. Sci Rep 7: 5642
Schuster, Stefan
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(2017) Antagonistic bacteria disrupt calcium homeostasis and immobilize algal cells. Nat Comm 8: 1756
Aiyar, Prasad; Schaeme, Daniel; García-Altares, María; Carrasco Flores, David; Dathe, Hannes; Hertweck, Christian; Sasso, Severin & Mittag, Maria
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(2017) Antibiotic-producing symbionts dynamically transition between plant pathogenicity and insect-defensive mutualism. Nat Comm 8: 15172
Flórez, Laura V.; Scherlach, Kirstin; Gaube, Paul; Ross, Claudia; Sitte, Elisabeth; Hermes, Cornelia; Rodrigues, Andre; Hertweck, Christian & Kaltenpoth, Martin
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(2017) De novo evolved interference competition promotes the spread of biofilm defectors. Nat comm 8: 15127
Martin, Marivic; Dragoš, Anna; Hölscher, Theresa; Maróti, Gergely; Bálint, Balázs; Westermann, Martin & Kovács, Ákos T.
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(2017) Discovery of an extended austinoid biosynthetic pathway in Aspergillus calidoustus. ACS Chem Biol 12: 1227
Valiante, Vito; Mattern, Derek J.; Schüffler, Anja; Horn, Fabian; Walther, Grit; Scherlach, Kirstin; Petzke, Lutz; Dickhaut, Joachim; Guthke, Reinhard; Hertweck, Christian; Nett, Markus; Thines, Eckhard & Brakhage, Axel A.
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(2017) Induced Chemical Defense of a Mushroom by a Double-Bond-Shifting Polyene Synthase. Angew Chem Int Ed 56: 5937
Brandt, Philip; García‐Altares, María; Nett, Markus; Hertweck, Christian & Hoffmeister, Dirk
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(2017) Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges. PNAS 114: E347
Lackner, Gerald; Peters, Eike Edzard; Helfrich, Eric J. N. & Piel, Jörn
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(2017) Insights into the red algae and eukaryotic evolution from the genome of Porphyra umbilicalis (Bangiophyceae, Rhodophyta). Proc Natl Acad Sci USA 114: E6361
Brawley, Susan H.; Blouin, Nicolas A.; Ficko-Blean, Elizabeth; Wheeler, Glen L.; Lohr, Martin; Goodson, Holly V.; Jenkins, Jerry W.; Blaby-Haas, Crysten E.; Helliwell, Katherine E.; Chan, Cheong Xin; Marriage, Tara N.; Bhattacharya, Debashish; Klein, Anita S.; Badis, Yacine; Brodie, Juliet; Cao, Yuanyu; Collén, Jonas; Dittami, Simon M.; Gachon, Claire M. M.; ... & Prochnik, Simon E.
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(2017) Metabolic Adaptation Establishes Disease Tolerance to Sepsis. Cell 169: 1263
Weis, Sebastian; Carlos, Ana Rita; Moita, Maria Raquel; Singh, Sumnima; Blankenhaus, Birte; Cardoso, Silvia; Larsen, Rasmus; Rebelo, Sofia; Schäuble, Sascha; Del Barrio, Laura; Mithieux, Gilles; Rajas, Fabienne; Lindig, Sandro; Bauer, Michael & Soares, Miguel P.
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(2017) Specificity of root microbiomes in native‐grown Nicotiana attenuata and plant responses to UVB increase Deinococcus colonization. Mol Ecol 26: 2543
Santhanam, Rakesh; Oh, Youngjoo; Kumar, Ramesh; Weinhold, Arne; Luu, Van Thi; Groten, Karin & Baldwin, Ian T.
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(2017) Sticking together: Inter-species aggregation of bacteria isolated from iron snow is controlled by chemical signaling. ISME J 11: 1075
Mori, Jiro F; Ueberschaar, Nico; Lu, Shipeng; Cooper, Rebecca E; Pohnert, Georg & Küsel, Kirsten
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(2017) Time-resolved diffraction of shock-released SiO2 and diaplectic glass formation. Nature Communications 8: 1481
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