EGFR-targeted polyglycerol-shelled multifunctional micellar drug conjugates for precision cancer chemotherapy

• Applicant: Professor Dr. Rainer Haag
• Subject Area: Biological and Biomimetic Chemistry ; Biomaterials ; Polymer Materials
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 392192146

• Final Report Year: 2022

Final Report Abstract

No abstract available

Publications

• J. Control. Release, 2019, 300, 13-21. Reductively cleavable polymer-drug conjugates based on dendritic polyglycerol sulfate and monomethyl auristatin E as anticancer drugs
  N. Rades, K. Achazi, M. Qiu, C. Deng, R. Haag, Z. Zhong, K. Licha
  
• J. Control Release, 2020, 329, 676-695. Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation
  W. Gu, F. Meng, R. Haag, Z. Zhong
  
• Adv. Mater. 2021, 33, 2007787. Daratumumab Immunopolymersome-Enabled Safe and CD38-Targeted Chemotherapy and Depletion of Multiple Myeloma
  N. Yu, Y. Zhang, J. Li, W. Gu, S. Yue, B. Li, F. Meng, H. Sun, R. Haag, J. Yuan, Z. Zhong
  
• Biomacromolecules 2021, 22, 6, 2625–2640. A toolbox of biodegradable dendritic (poly glycerol sulfate)-SS-poly(ester) micelles for cancer treatment: stability, drug release, and tumor targeting
  D. Braatz, M. Dimde, G. Ma, Y. Zhong, M. Tully, C. Grötzinger, Y. Zhang, A. Mavroskoufis, M. Schirner, Z. Zhong, M. Ballauff, R. Haag
  
• J. Control Release, 2021, 340, 331-341. An intelligent cell-selective polymersome-DM1 nanotoxin toward triple negative breast cancer
  Y. Zhang, S. Yue, R. Haag, H. Sun, Z. Zhong