Assembly and signal-mediated regulation of the androgen receptor/LSD1 histone demethylation complex (P02)

• Subject Area: Cell Biology
• Term: from 2007 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 26068018

The lysine-specific demethylase 1 (LSD1) is phosphorylated by protein kinase C and methylated by the histone methyltransferase G9a/GLP. Presence or absence of these posttranslational modifications on LSD1 (the combinatorial code) dictates recruitment or eviction of chromatin modifiers that interpret and transduce the information into physiological traits. Consequently, we shall (i) decipher the LSD1 "combinatorial code" by structure-function and crystal structure analyses. We shall (ii) characterise the function of the combinatorial code in physiology and pathology by combining genome-wide binding and transcriptome analyses with genetically modified mouse models.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 746: Functional Specificity by Coupling and Modification of Proteins
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Roland Schüle