Charakterisierung ribosomaler Stalling-Sequenzen und deren Erkennung durch RQT Qualitätskontroll-Faktoren

• Antragsteller: Professor Dr. Roland Beckmann
• Fachliche Zuordnung: Strukturbiologie ; Biochemie
• Förderung: Förderung von 2018 bis 2021
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 394323889

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways. EMBO J. 2019 38
  Ikeuchi, Ken; Tesina, Petr; Matsuo, Yoshitaka; Sugiyama, Takato; Cheng, Jingdong; Saeki, Yasushi; Tanaka, Keiji; Becker, Thomas; Beckmann, Roland & Inada, Toshifumi
  
• Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts. EMBO J. 2020 39, e103365
  Tesina, Petr; Lessen, Laura N; Buschauer, Robert; Cheng, Jingdong; Wu, Colin Chih‐Chien; Berninghausen, Otto; Buskirk, Allen R; Becker, Thomas; Beckmann, Roland & Green, Rachel
  
• Structural and mutational analysis of the ribosome-arresting human XBP1u. eLife 2019; 8:e46267
  Shanmuganathan, Vivekanandan; Schiller, Nina; Magoulopoulou, Anastasia; Cheng, Jingdong; Braunger, Katharina; Cymer, Florian; Berninghausen, Otto; Beatrix, Birgitta; Kohno, Kenji; von Heijne, Gunnar & Beckmann, Roland
  
• Structure and function of Vms1 and Arb1 in RQC and mitochondrial proteome homeostasis. Nature 2019 570, 538–542
  Su, Ting; Izawa, Toshiaki; Thoms, Matthias; Yamashita, Yui; Cheng, Jingdong; Berninghausen, Otto; Hartl, F. Ulrich; Inada, Toshifumi; Neupert, Walter & Beckmann, Roland
  
• Structure of the 80S ribosome–Xrn1 nuclease complex. Nat. Struct. Mol. Biol. 2019. 26(4):p. 275-280
  Tesina, Petr; Heckel, Elisabeth; Cheng, Jingdong; Fromont-Racine, Micheline; Buschauer, Robert; Kater, Lukas; Beatrix, Birgitta; Berninghausen, Otto; Jacquier, Alain; Becker, Thomas & Beckmann, Roland
  
• RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1. Nat Struct Mol Biol 2020 27, 323-332
  Matsuo, Yoshitaka; Tesina, Petr; Nakajima, Shizuka; Mizuno, Masato; Endo, Akinori; Buschauer, Robert; Cheng, Jingdong; Shounai, Okuto; Ikeuchi, Ken; Saeki, Yasushi; Becker, Thomas; Beckmann, Roland & Inada, Toshifumi
  
• Structural basis of L-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide. Nucleic Acids Res 2021 49, 9539-9547
  Su, Ting; Kudva, Renuka; Becker, Thomas; Buschauer, Robert; Komar, Tobias; Berninghausen, Otto; von Heijne, Gunnar; Cheng, Jingdong & Beckmann, Roland