Regulation and execution of vesicle formation in clathrin-independent endocytosis (A09)

• Subject Area: Cell Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833

Viruses exploit existing cellular mechanisms for transport across dynamic cellular interfaces. During cell invasion, human papillomaviruses (HPV) use a unique clathrin-independent endocytic pathway that we term WASH-mediated endocytosis (WASH-ME). Here, we will analyze how phosphoinositides and BAR-domain-containing proteins contribute to vesicle formation at the plasma membrane, and how the extracellular matrix constituent laminin-332 regulates the intracellular cargo destination of WASH-ME by following HPV as a model cargo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1348: Dynamic cellular interfaces: formation and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Mario Schelhaas