Regulation and execution of vesicle formation in WASH-mediated endocytosis (A09)

• Subject Area: Cell Biology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 386797833

Particularly upon cell invasion, viruses exploit existing cellular mechanisms to transport their genomes across dynamic cellular interfaces to the site of viral replication. Human papillomaviruses (HPV) utilize a unique emerging endocytic pathway, while it remains unknown what cellular cargo normally uses this pathway. We propose to elucidate function and execution of this unique mechanism that we termed WASH-mediated endocytosis (WASH-ME) by following HPV uptake into cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1348: Dynamic cellular interfaces: formation and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Mario Schelhaas