Regulation of myelinated axon structure by communication between axons and oligodendrocytes (A14*)

• Subject Area: Developmental Neurobiology
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 118803580

Myelination by oligodendrocytes critically regulates structure, function, and survival of axons in the central nervous system through mechanisms that are not well understood. Here, we will use in vivo live cell imaging and genetic manipulations in zebrafish as model organism to elucidate the mechanisms by which axons and surrounding oligodendrocytes communicate to form, remodel and maintain myelinated axons and how this is controlled by cell intrinsic and extrinsic mechanisms.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 870: Assembly and Function of Neuronal Circuits in Sensory Processing
• International Connection: United Kingdom
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Tim Czopka, Ph.D.