Mechanics of Nucleosome Array Assembly (B12*)

• Subject Area: Biophysics
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 111166240

Nucleosome positions within nucleosome arrays are determined by an interplay of nucleosome-nucleosome interactions, DNA sequence-dependent nucleosome stability, and active chromatin remodeling. Here, we study how the observed nucleosome gas statistics can robustly emerge from the underlying mechanisms, and how these mechanisms permit the rapid re-establishment of nucleosome arrays after they have been disrupted, e.g. during DNA replication. We will employ combinations of methods from statistical and soft-matter physics.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 863: Forces in Biomolecular Systems
• Applicant Institution: Technische Universität München (TUM)
• Project Head: Professor Dr. Ulrich Gerland