Epigenetic regulation of TGF-ß/BMP signaling and of EMT control of colon cancer invasion (B09*)

• Subject Area: Biochemistry ; Cell Biology
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987

A link between TGF-ß activated SMAD2 and -3 and the MLL4 histone H3K4 methylation complex has been identified previously. The relation between wild type and mutants of SMAD2, -3 and -4 and epigenetic control of TGF-ß signaling will be investigated in colorectal cancer cells providing a better understanding as to how epigenetic control by the TGF-ß activated SMADs can be exploited to develop novel intervention strategies to suppress metastasis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Marc Timmers