The role of the soluble epoxide hydrolase in the regulation of vascular stability/integrity (B13*)

• Subject Area: Anatomy and Physiology
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 75732319

The major focus of this project is on clarifying the role of the soluble epoxide hydrolase (sEH) in the events underlying the altered vascular architecture in the retina and heart that ultimately result in microvascular dysfunction and retinopathy/vascular rarefication in diabetic mice and humans. There is a strong focus on the demonstration of cause and effect between increased sEH expression, increased production of specific diol intermediates and the dissolution of pericyte-endothelial cell junctions. Importantly, the effectiveness of sEH inhibitors in preventing vascular changes as well as promoting vascular repair will be assessed.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 834: Endothelial Signalling and Vascular Repair
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professorin Ingrid Fleming, Ph.D.