Project Details
Projekt
Dynamic imaging and modelling of the regulation of T cell - pathogen equilibration during chronic infection (B31*)
Subject Area
Immunology
Term
from 2018 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925
This project investigates the molecular signaling and cellular dynamics underlying the equilibration between the immune response and persisting pathogens in the course of a chronic infection. Using a combination of dynamic in vivo imaging and mathematical modelling of Leishmania major infection, B31N will establish the impact of effector and regulatory T cell functions on pathogen physiology. Furthermore, the activation of T cells will be assessed in the context of their cellular interactions in vivo. The experimental data obtained will be used to inform agent-based and differential equation models in order to study the evolution of immune cell and pathogen populations as well as the dynamics of T cell activation signaling.
DFG Programme
Collaborative Research Centres
Applicant Institution
Otto-von-Guericke-Universität Magdeburg
Project Heads
Professor Dr. Michael Meyer-Hermann; Professor Dr. Andreas Müller
