Mechanisms of O6-methylguanine induced senescence and transcriptional repression in glioblastoma cells

• Applicants: Professor Dr. Markus Christmann; Professor Dr. Bernd Kaina
• Subject Area: Public Health, Healthcare Research, Social and Occupational Medicine
• Term: from 2018 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 398037827

• Final Report Year: 2022

No abstract available

Publications

• Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?. International Journal of Molecular Sciences, 20(7), 1562.
  He, Yang & Kaina, Bernd
  
• The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death. Molecular Cancer Research, 17(5), 1129-1141.
  He, Yang; Roos, Wynand P.; Wu, Qianchao; Hofmann, Thomas G. & Kaina, Bernd
  
• Accumulation of Temozolomide-Induced Apoptosis, Senescence and DNA Damage by Metronomic Dose Schedule: A Proof-of-Principle Study with Glioblastoma Cells. Cancers, 13(24), 6287.
  Beltzig, Lea; Stratenwerth, Björn & Kaina, Bernd
  
• Localization matters: nuclear-trapped Survivin sensitizes glioblastoma cells to temozolomide by elevating cellular senescence and impairing homologous recombination. Cellular and Molecular Life Sciences, 78(14), 5587-5604.
  Reich, Thomas R.; Schwarzenbach, Christian; Vilar, Juliana Brandstetter; Unger, Sven; Mühlhäusler, Fabian; Nikolova, Teodora; Poplawski, Alicia; Baymaz, H. Irem; Beli, Petra; Christmann, Markus & Tomicic, Maja T.
  
• Molecular Dosimetry of Temozolomide: Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold Doses. Molecular Cancer Therapeutics, 20(10), 1789-1799.
  Stratenwerth, Björn; Geisen, Susanne M.; He, Yang; Beltzig, Lea; Sturla, Shana J. & Kaina, Bernd
  
• Oxaliplatin-Induced Senescence in Colorectal Cancer Cells Depends on p14ARF-Mediated Sustained p53 Activation. Cancers, 13(9), 2019.
  Tomicic, Maja T.; Krämer, Franziska; Nguyen, Alexandra; Schwarzenbach, Christian & Christmann, Markus
  
• Targeting c-IAP1, c-IAP2, and Bcl-2 Eliminates Senescent Glioblastoma Cells Following Temozolomide Treatment. Cancers, 13(14), 3585.
  Schwarzenbach, Christian; Tatsch, Larissa; Brandstetter, Vilar Juliana; Rasenberger, Birgit; Beltzig, Lea; Kaina, Bernd; Tomicic, Maja T. & Christmann, Markus
  
• Abrogation of Cellular Senescence Induced by Temozolomide in Glioblastoma Cells: Search for Senolytics. Cells, 11(16), 2588.
  Beltzig, Lea; Christmann, Markus & Kaina, Bernd
  
• Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells. Cancers, 14(9), 2233.
  Beltzig, Lea; Schwarzenbach, Christian; Leukel, Petra; Frauenknecht, Katrin B. M.; Sommer, Clemens; Tancredi, Alessandro; Hegi, Monika E.; Christmann, Markus & Kaina, Bernd