Facts and Figures: Neuro-functional foundations and cognitive processes of numerical magnitude processing and arithmetic fact retrieval
Final Report Abstract
What can we learn from brain damage about numerical processes in the healthy brain? This was one of the central questions of this project. Two basic processes are distinguished in number processing: numerical magnitude processing and arithmetic fact retrieval. The distinction between these processes and their neurocognitive correlates is still controversial. In parallelized studies, we investigated the neurocognitive correlates of both processes in stroke patients and healthy controls. The parallelized experimental design enabled us to ask and answer similar questions regarding the characteristics of magnitude processing and fact retrieval in stroke patients and healthy controls. The application of recently developed disconnectome mapping to stroke lesions allowed us to identify causal relationships between fact retrieval and its neuro-functional and neuro-structural correlates for the first time in numerical cognition. Furthermore, spatial-numerical associations (e.g., in neglect patients) were studied as a pathological model for unimpaired magnitude processing such as proportions. In parallel, using visual hemifield stimulation, we investigated causal assumptions regarding fact retrieval and numerical magnitude in healthy control participants, in whom the influence of pathological interferences is excluded. Similarly, we induced transient neglect in healthy participants by using vestibular stimulation to investigate spatial-numerical associations while ruling out the influence of pathological interference. Our results led, among others, to the formulation of the Two-Network Framework (TNF) of numerical cognition. Based on the TNF, we developed a classification schema of phenomenological subtypes and their underlying neural origin. Our project advances our understanding of (un)impaired number processing and enables implications for the diagnosis and treatment of acalculia and dyscalculia.
Publications
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Developmental Dyscalculia in Adults. Lernen und Lernstörungen, 9(2), 126-137.
Kaufmann, Liane; von Aster, Michael; Göbel, Silke M.; Marksteiner, Josef & Klein, Elise
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From Letters to Words, from Digits to Numbers: Similarities, Differences, and Modal Influence on Writing Processes from Different Perspectives. Dissertation (Psychology), Eberhardt Karls University of Tuebingen
Jung, S.
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Hemispheric Lateralization of Arithmetic Facts and Magnitude Processing for Two-Digit Numbers. Frontiers in Human Neuroscience, 14.
Jung, Stefanie; Moeller, Korbinian; Karnath, Hans-Otto & Klein, Elise
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Hemisphärische Lateralisierung von arithmetischen Fakten in einem Verifikationsparadigma mit tachistoskopischer Darbietung. Psychologie und Gehirn. Freiburg, Germany. (Conference cancelled). [Poster]
Jung, S.; Janssen, R.; Moeller, K.; Karnath, H.-O. & Klein, E.
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The strategy matters: Bounded and unbounded number line estimation in secondary school children. Cognitive Development, 53, 100839.
Jung, Stefanie; Roesch, Stephanie; Klein, Elise; Dackermann, Tanja; Heller, Juergen & Moeller, Korbinian
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A neuropsychological perspective on the development of and the interrelation between numerical and language processing. Diversity Dimensions in Mathematics and Language Learning, 40-64. De Gruyter.
Klein, Elise; Jung, Stefanie & Kaufmann, Liane
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Drawing the line – the cognitive framing of line bisection changes anchor point perception. 46. Jahrestagung Psychologie und Gehirn (PuG, online conference). Tuebingen. Deutschland [Poster]
Smaczny, S.; Jung, S.; Klein, E.; J.; Moeller, K. & Karnath, H.-O.
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Editorial: Neuro-cognitive Architecture of Numerical Cognition and Its Development. Frontiers in Human Neuroscience, 15.
Klein, Elise; Babai, Reuven; Ischebeck, Anja & Moeller, Korbinian
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Facts and Figures: Zwei Studien zur hemisphärischen Spezialisierung des Abrufs arithmetischer Fakten. 46. Jahrestagung Psychologie und Gehirn (PuG, online conference). Tuebingen. Deutschland [Poster]
Jung, S.; Janssen, R.; Moeller, K.; Karnath, H.-O. & Klein, E.
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Mode effect: An issue of perspective? Writing mode differences in a spelling assessment in German children with and without developmental dyslexia. Dyslexia, 27(3), 373-410.
Jung, Stefanie; Moeller, Korbinian; Klein, Elise & Heller, Juergen
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No hemispheric specialization of arithmetic fact retrieval in simple multiplication. 39th European Workshop of Cognitive Neuropsychology. (online Konferenz). Bressanone. Italien [Vortrag]
Jung, S.; Janssen, R. & Klein, E.
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Laterality in simple multiplication: Assessing hemispheric specialization of arithmetic fact retrieval in a visual hemifield paradigm.. Journal of Experimental Psychology: Human Perception and Performance, 48(4), 351-369.
Jung, Stefanie; Janssen, Roman J. & Klein, Elise
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Left angular gyrus disconnection impairs multiplication fact retrieval. 40th European Workshop on Cognitive Neuropsychology. Bressanone, Italy. [Talk]
Smaczny, S.; Sperber, C.; Jung, S.; Moeller, K.; Karnath, H.-O. & Klein, E.
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Left angular gyrus disconnection impairs multiplication fact retrieval. Mathematical Cognition and Learning Society Conference (MCLS) 2022. Antwerpen, Belgium. [Talk]
Smaczny, S.; Sperber, C.; Jung, S.; Moeller, K.; Karnath, H.-O. & Klein, E.
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Left parietal disconnection most strongly impairs multiplication fact retrieval. 5th Neuropsychology Summer School of the Federation of the European Societies of Neuropsychology (FESN). Berlin. [Poster]
Smaczny, S.; Sperber, C.; Jung, S. & Klein, E.
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The line bisection bias stems from left-side underawareness, not from right-side hyperattention. Cold Spring Harbor Laboratory.
Smaczny, S.; Klein, E.; Jung, S.; Moeller, K. & Karnath, H.-O.
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Challenges in Understanding Numerical Learning: Editorial for Brain Sciences Special Issue “Neurocognitive Signatures of Math (Learning) across the Lifespan and Their Interrelation with Other Aspects of Cognition and Emotion”. Brain Sciences, 13(3), 420.
Klein, Elise; Zamarian, Laura & Kaufmann, Liane
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Disconnection in a left-hemispheric temporo-parietal network impairs multiplication fact retrieval. NeuroImage, 268, 119840.
Smaczny, S.; Sperber, C.; Jung, S.; Moeller, K.; Karnath, H.O. & Klein, E.
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Numbers, lines, and the effect of test mode in the elderly. Mathematical Cognition and Learning Society Conference (MCLS) 2023, Loughborough, UK. (Talk)
Klein, E.; Janssen, R. & Jung S.
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The two-network framework of number processing: a step towards a better understanding of the neural origins of developmental dyscalculia. Journal of Neural Transmission, 130(3), 253-268.
Klein, Elise & Knops, André
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Visuo-spatial processes in number line estimation – Evidence from Neglect. 65th annual meeting of the General Psychology section of the German Psychological Society (TeaP), Trier, Germany. (Talk)
Smaczny, S.; Jung, S.; Klein, E.; Moeller, K. & Karnath, H.-O.
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Visuo-spatial processes in number line estimation – Evidence from spatial neglect. 41th European Workshop on Cognitive Neuropsychology. Bressanone, Italy. [Poster]
Smaczny, S.; Klein, E.; Jung, S.; Moeller, K. & Karnath, H.-O.
