Investigation of vascular reorganization in early AMD

• Applicant: Professor Dr. Ulrich Schraermeyer, since 10/2019
• Subject Area: Ophthalmology ; Cell Biology
• Term: from 2017 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 401013432

• Final Report Year: 2023

No abstract available

Publications

• A new rat model of treatment-naive quiescent choroidal neovascularization induced by human VEGF165 overexpression. Biology Open.
  Liu, Shan; Biesemeier, Antje K.; Tschulakow, Alexander V.; Thakkar, Harsh V.; Julien-Schraermeyer, Sylvie & Schraermeyer, Ulrich
  
• Melanosomes degrade lipofuscin and precursors that are derived from photoreceptor membrane turnover in the retinal pigment epithelium—an explanation for the origin of the melanolipofuscin granule. Cold Spring Harbor Laboratory.
  Lyu, Yanan; Tschulakow, Alexander V. & Schraermeyer, Ulrich
  
• Pigment Epithelium‐Derived Factor Protects Retinal Neural Cells and Prevents Pathological Angiogenesis in an Ex Vivo Ischemia Model. Oxidative Medicine and Cellular Longevity, 2022(1).
  Xi, Lei; Tikhonovich, Marina; Biesemeier, Antje; Julien-Schraermeyer, Sylvie; Schraermeyer, Ulrich & Tschulakow, Alexander V.
  
• Removal of RPE lipofuscin results in rescue from retinal degeneration in a mouse model of advanced Stargardt disease: Role of reactive oxygen species. Free Radical Biology and Medicine, 182, 132-149.
  Fang, Yuan; Taubitz, Tatjana; Tschulakow, Alexander V.; Heiduschka, Peter; Szewczyk, Grzegorz; Burnet, Michael; Peters, Tobias; Biesemeier, Antje; Sarna, Tadeusz; Schraermeyer, Ulrich & Julien-Schraermeyer, Sylvie
  
• Chemiexcitation and melanin in photoreceptor disc turnover and prevention of macular degeneration. Proceedings of the National Academy of Sciences, 120(20).
  Lyu, Yanan; Tschulakow, Alexander V.; Wang, Kun; Brash, Douglas E. & Schraermeyer, Ulrich