The foundations of specific radiobiological effects generated by laser-accelerated protons

• Applicants: Professor Dr. Friedrich Boege; Professor Dr. George Iliakis; Professor Dr. Christoph V. Suschek; Professor Dr. Oswald Willi
• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 401832363

• Final Report Year: 2023

No abstract available

Publications

• An online beam profiler for laser-accelerated protons. Review of Scientific Instruments, 90(5).
  Schwind, K. M.; Aktan, E.; Prasad, R.; Cerchez, M.; Eversheim, D.; Willi, O. & Aurand, B.
  
• Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer. Cancers, 11(11), 1671.
  Iliakis, George; Mladenov, Emil & Mladenova, Veronika
  
• Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase. Scientific Reports, 9(1).
  Mladenov, Emil; Fan, Xiaoxiang; Dueva, Rositsa; Soni, Aashish & Iliakis, George
  
• Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52. Nucleic Acids Research, 48(4), 1905-1924.
  Mladenov, Emil; Staudt, Christian; Soni, Aashish; Murmann-Konda, Tamara; Siemann-Loekes, Maria & Iliakis, George
  
• An experimental platform for studying the radiation effects of laser accelerated protons on mammalian cells. AIP Advances, 11(6).
  Ehlert, J.; Piel, M.; Boege, F.; Cerchez, M.; Haas, R.; Iliakis, G. E.; Prasad, R.; Willi, O. & Monzel, C.
  
• Strong Shift to ATR-Dependent Regulation of the G2-Checkpoint after Exposure to High-LET Radiation. Life, 11(6), 560.
  Mladenova, Veronika; Mladenov, Emil; Scholz, Michael; Stuschke, Martin & Iliakis, George
  
• Technical note: Providing proton fields down to the few‐MeV level at clinical pencil beam scanning facilities for radiobiological experiments. Medical Physics, 49(1), 666-674.
  Behrends, Carina; Bäumer, Christian; Verbeek, Nico; Ehlert, Jens; Prasad, Rajendra; Wulff, Jörg; Lühr, Armin & Timmermann, Beate
  
• Increased Gene Targeting in Hyper-Recombinogenic LymphoBlastoid Cell Lines Leaves Unchanged DSB Processing by Homologous Recombination. International Journal of Molecular Sciences, 23(16), 9180.
  Mladenov, Emil; Paul-Konietzko, Katja; Mladenova, Veronika; Stuschke, Martin & Iliakis, George
  
• Increased Resection at DSBs in G2-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ. Cells, 11(13), 2099.
  Xiao, Huaping; Li, Fanghua; Mladenov, Emil; Soni, Aashish; Mladenova, Veronika; Pan, Bing; Dueva, Rositsa; Stuschke, Martin; Timmermann, Beate & Iliakis, George