Synthesis and characterization of low-molecular modulators of epigenetic target enzymes (C06)

• Subject Area: Biochemistry
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 325871075

In this project novel inhibitors of histone modifying enzymes, in special type III histone deacetylases (sirtuins), will be developed. Based on our own previous work (for project A) and recently published lead structures (for project B), new, unprecedented chemotypes of inhibitors will be designed. These inhibitors will be valuable chemical tools for cooperating groups in the SFB. Optimization of the inhibitors will be fostered by contributions from other groups in the consortium.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1309: Chemical Biology of Epigenetic Modifications
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Franz Bracher