Die physiologische Bedeutung der oxLDL abhängigen LOX-1 Rezeptor Aktivierung in Granulosazellen verweist auf die Autophagie als neuer Form der Follikelatresie

Applicant Professorin Dr. Katharina Spanel-Borowski

Subject Area Nuclear Medicine, Radiotherapy, Radiobiology

Term from 2007 to 2012

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 40199371

Final Report Year 2009

Final Report Abstract

No abstract available

Elevated levels of oxidised low-density lipoprotein and of catalase activity in follicular fluid of obese women. Mol Hum Reprod. 2009 Sep 3. [Epub ahead of print]
Bausenwein J, Serke H, Eberle K, Hirrlinger J, Jogschies P, Hmeidan FA, Blumenauer V, Spanel-Borowski K
Granulosa cell subtypes respond by autophagy or cell death to oxLDL-dependent activation of the oxidized lipoprotein receptor 1 and toll-like 4 receptor. Autophagy. 2009 5:991-1003
Serke H, Vilser C, Nowicki M, Hmeidan FA, Blumenauer V, Hummitzsch K, Lösche A, Spanel-Borowski K
The variable expression of lectin-like oxidized low-density lipoprotein receptor (LOX-1) and signs of autophagy and apoptosis in freshly harvested human granulosa cells depend on gonadotropin dose, age, and body weight. Fertil Steril. 2009 Mar 31. [Epub ahead of print]
Vilser C, Hueller H, Nowicki M, Hmeidan FA, Blumenauer V, Spanel-Borowski K
Granulosa cell subtypes vary in response to oxidized lowdensity lipoprotein treatment as regards specific lipoprotein receptors and antioxidant enzyme activity. J Clin Endocrinol Metabol
Serke H, Bausenwein J, Hirrlinger J, Vilser C, Jogschies P, Hmeidan FA, Blumenauer V, Spanel-Borowski K