Project Details
Projekt Print View

Structural and functional effects of circumscribed temporal lobe resections

Subject Area Clinical Neurology; Neurosurgery and Neuroradiology
Term from 2018 to 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 403231417
 
Final Report Year 2022

Final Report Abstract

Epilepsy affects nearly 1% of the world´s population, leading to substantial morbidity and mortality. Hippocampal sclerosis (HS) is the histological hallmark of temporal lobe epilepsy (TLE), the most common drug-refractory syndrome. Nevertheless, in approximately 25% of all TLE patients, seizures originate from neocortical lesions. Moreover, the ipsilateral hippocampus is considered structurally and functionally intact in such patients, allowing for circumscribed lesionectomy without hippocampectomy. Consequently, our purpose was to comprehensively evaluate brain morphology and network topology in neocortical TLE, relative to HS and healthy controls. Based on evidence of widespread structural abnormalities in mesiotemporal TLE, we hypothesize that neocortical TLE equally causes structural alterations distant to the seizure focus, including the hippocampus.

Publications

 
 

Additional Information

Textvergrößerung und Kontrastanpassung