Epigenetic regulation of TFIID recruitment and activity (A07)

• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2018 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 192904750

Epigenetic control of chromatin states is tightly linked to the transcriptional programmes of cells. The basal transcription factor TFIID acts at the crossroads between gene activation signals and RNA polymerase II transcription machinery. We aim to dissect the contributions of histone modifications and chromatin binding dynamics to the function of human promoters. The results of our study will provide a detailed understanding of the epigenetic mechanisms controlling gene transcription and differentiation in mammalian cells

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 992: Medical Epigenetics (MEDEP) - From Basic Mechanisms to Clinical Applications
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Marc Timmers